의약품 상세정보 표입니다.
제품명	퀸락정50mg [Qinlock Tab. 50mg]
성분 / 함량	리프레티닙 50mg
전문 / 일반	전문(희귀)
단일 / 복합	단일
제조 / 수입사	한국오노약품공업
제형	정제
투여경로	경구(내용고형)
성상	흰색에서 미백색의 타원형 정제
허가일	허가일: 2026년 10월 16일
대조 / 생동
급여정보	Onetwo0825O
ATC코드
KPIC 약효분류
제품설명서
포장단위 (식약처 기준)	30정/병
저장방법	기밀용기, 실온보관 (1~30ºC)

용법 · 용량

항암제 사용 경험이 있는 의사의 감독하에 치료를 시작하고 모니터링해야 한다.

1) 권장용량

이 약의 1일 권장 투여 용량은 리프레티닙으로서 150mg(이 약 50mg 정제 3정에 해당)이며, 음식물 섭취와 관계없이 매일 같은 시간에 1일 1회 경구 투여한다.

이 약은 물과 함께 통째로 삼켜야 하며, 자르거나, 부수거나, 씹어서는 안 된다.

이 약은 질병의 진행을 확인하거나 수용할 수 없는 독성이 나타날 때까지 투여한다.

2) 투여를 잊은 경우

예정 투여 시간으로부터 8시간이 지나지 않은 경우, 즉시 투여한다. 다음 용량은 예정 시간에 투여한다. 예정 투여 시간으로부터 8시간이 지난 경우, 다음 예정된 시간에 투여한다. 잊은 용량을 보충하기 위하여 추가 용량을 투여해서는 안 된다.

이 약 투여 후 구토가 있는 경우, 추가 용량을 투여해서는 안된다. 다음 용량은 예정된 시간에 투여한다.

3) 이상반응에 따른 용량 조절

이상반응 관리를 위해 안전성과 내약성에 기반하여 이 약의 투여 일시 중단, 용량 감량 또는 투여 중단이 필요할 수 있다.

이상반응 발생 시, 이 약을 1일 1회 100mg으로 감량한다. 감량한 후에도 견디지 못하는 환자는 이 약의 투여를 영구 중단한다.

권장용량 조절은 표 1과 같다(사용상의 주의사항 ‘2. 다음 환자에는 신중히 투여할 것’ 및 ‘3. 이상반응’ 참조).

표 1. 이상반응 관련 권장 용량 조절

이상반응	중증도^a	권장 용량 조절
손바닥-발바닥 홍반성 감각 이상 증후군(Palmar-Plantar Erythrodysaesthesia Syndrome, PPES) (‘4. 일반적 주의’ 참조)	2등급	ㆍ1등급 이하 또는 기저 상태로 회복할 때까지 이 약의 투여를 일시 중단한다. 7일 이내 회복한 경우, 동일 용량으로 투여를 다시 시작한다. 7일 이내에 회복하지 않는 경우, 이 약을 감량하여 투여를 다시 시작한다. ㆍ이상반응이 1등급 이하 또는 기저 상태로 최소 28일간 유지한 경우, 이 약을 다시 증량하는 것을 고려할 수 있다. ㆍ재발한 경우, 1등급 이하 또는 기저 상태로 회복할 때까지 이 약의 투여를 일시 중단한다. 이후 회복 기간과 관계없이 이 약을 감량하여 투여를 다시 시작한다.
	3등급	ㆍ1등급 이하 또는 기저 상태로 회복할 때까지 이 약의 투여를 최소 7일간(최대 28일간) 일시 중단한다. 이후 감량된 용량으로 투여를 다시 시작한다. ㆍ이상반응이 1등급 이하 또는 기저 상태로 최소 28일간 유지한 경우, 이 약을 다시 증량하는 것을 고려할 수 있다.
고혈압 (‘2. 다음 환자에는 신중히 투여할 것’ 참조)	3등급	ㆍ증상이 있는 경우, 증상이 사라지고 혈압이 조절될 때까지 이 약의 투여를 일시 중단한다. ㆍ혈압이 1등급 이하 또는 기저 상태로 조절될 때, 동일 용량으로 투여를 다시 시작한다. 그렇지 않은 경우, 이 약을 감량하여 투여를 다시 시작한다. ㆍ재발한 경우, 증상이 사라지고 혈압이 조절될 때까지 이 약의 투여를 일시 중단한다. 이후 이 약을 감량하여 투여를 다시 시작한다.
고혈압 (‘2. 다음 환자에는 신중히 투여할 것’ 참조)	4등급	이 약의 투여를 영구적으로 중단한다.
좌심실 수축기 기능 장애 (‘2. 다음 환자에는 신중히 투여할 것’ 참조)	3등급 또는 4등급	이 약의 투여를 영구적으로 중단한다.
관절통 또는 근육통 (‘3. 이상반응’ 참조)	2등급	ㆍ1등급 이하 또는 기저 상태로 회복할 때까지 이 약의 투여를 일시 중단한다. 7일 이내에 회복한 경우, 동일 용량으로 투여를 다시 시작한다. 7일 이내에 회복하지 않는 경우, 이 약을 감량하여 투여를 다시 시작한다. ㆍ이상반응이 1등급 이하 또는 기저 상태로 최소 28일간 유지한 경우, 이 약을 다시 증량하는 것을 고려할 수 있다. ㆍ이상반응이 재발한 경우, 1등급 이하 또는 기저 상태로 회복할 때까지 이 약 투여를 일시 중단한다. 이후 회복 기간과 관계없이 이 약을 감량하여 투여를 다시 시작한다.
관절통 또는 근육통 (‘3. 이상반응’ 참조)	3등급	ㆍ1등급 이하 또는 기저 상태로 회복할 때까지 이 약의 투여를 최소 7일간(최대 28일간) 일시 중단한다. 이후 감량된 용량으로 투여를 다시 시작한다. ㆍ1등급 이하 또는 기저 상태로 최소 28일간 유지한 경우, 이 약을 다시 증량하는 것을 고려할 수 있다.
기타 이상반응 (‘3. 이상반응’ 참조)	3등급 또는 4등급	ㆍ이상반응이 1등급 이하 또는 기저 상태로 회복할 때까지(최대 28일간) 일시 중단한다. 이후 이 약을 감량하여 투여를 다시 시작한다. 그렇지 않은 경우, 이 약의 투여를 영구적으로 중단한다. ㆍ최소 28일간 재발하지 않은 경우, 이 약을 다시 증량하는 것을 고려할 수 있다. ㆍ재발한 경우, 이 약의 투여를 영구적으로 중단한다.
^a미국 국립 암연구소 이상반응 공통용어기준(NCI CTCAE) 버전 4.03

4) 강력한 또는 중등도 CYP3A 유도제와 병용 시 용량 조절

이 약은 강력한 또는 중등도 CYP3A 유도제와 병용투여 하지 않는다. 다만, 병용투여가 불가피한 경우, 이 약을 1회 150mg, 1일 2회로 증량한다. 환자의 임상적 반응 및 내약성을 면밀히 모니터링 해야 한다.

강력한 또는 중등도 CYP3A 유도제와 이 약을 병용 중인 환자가 투여를 잊은 경우(이 약을 1일 2회 복용)

◦예정 투여 시간으로부터 4시간이 지나지 않은 경우, 즉시 투여한다. 이후 다음 예정된 시간에 투여한다.

◦예정 투여 시간으로부터 4시간 이상 지난 경우, 잊은 용량은 투여하지 않고 다음 예정된 시간에 투여한다.(사용상의 주의사항 ‘5. 상호작용’ 참조).

사용상의 주의사항

1. 다음 환자에는 투여하지 말 것

1) 이 약 또는 이 약의 구성성분에 과민반응이 있는 환자

2) 이 약은 유당을 함유하고 있으므로, 갈락토오스 불내성(galactose intolerance), Lapp 유당분해효소 결핍증(Lapp lactase deficiency) 또는 포도당 ‑갈락토오스 흡수장애(glucose ‑galactose malabsorption) 등의 유전적인 문제가 있는 환자에게 투여해서는 안 된다.

2. 다음 환자에는 신중히 투여할 것

1) 원발성 피부 악성종양 위험이 있는 환자

이 약 투여 중 피부 편평 세포 암종 또는 흑색종이 나타났다.

이 약의 투여를 시작할 때와 치료 중에는 피부 상태를 정기적으로 평가해야 한다. 의심스러운 피부 병변은 절제하여 피부병리학적 평가를 실시한다.

원발성 피부 악성종양을 확인한 경우에도 이 약은 같은 용량으로 투여를 지속한다.

2) 고혈압 환자

이 약 투여 중 3등급을 포함한 고혈압이 나타났다(사용상의 주의사항 ‘3. 이상반응’ 참조).

조절 불가능한 고혈압 환자의 경우 이 약의 투여를 시작하지 않는다.

이 약의 투여를 시작하기 전에 혈압을 적절히 조절해야 한다. 이 약의 투여 중 임상적으로 필요한 경우 혈압을 모니터링한다.

중증도에 따라 이 약 투여를 일시 중단하거나 동일한 용량 또는 감량한 용량으로 투여 재개 또는 영구적으로 투여를 중단한다(용법용량 ‘3) 이상반응에 따른 용량 조절’ 참조).

3) 심장 기능 장애 환자

이 약을 투여한 환자에서 심부전, 급성 좌심실 부전, 이완기 기능 장애 및 심실 비대증, 심허혈성 사건(급성 관상 동맥 증후군 및 심근경색 등)을 포함한 심장 기능 장애가 나타났으며, 3등급 박출률 감소도 나타났다.

임상적으로 필요한 경우, 이 약 투여 시작 전과 투여 중 심장초음파 검사 또는 MUGA 스캔(multiple gated acquisition scan)을 통해 박출률을 평가해야 한다.

3등급 또는 4등급 좌심실 수축기 기능 장애가 발생한 경우, 이 약 투여를 영구적으로 중단한다(용법용량 ‘3) 이상반응에 따른 용량 조절’ 참조).

좌심실 박출률(LVEF)이 50% 미만 환자에서 이 약의 안전성을 평가한 자료는 없다.

4) 상처 치유 지연 위험이 있는 환자

혈관 내피 성장 인자(VEGF) 신호 전달 경로를 억제하는 약물을 투여받는 환자에서 상처 치유 지연이 발생하여 합병증이 나타날 수 있다.

이 약은 상처 치유를 저해할 수 있으므로, 환자가 수술을 받을 예정인 경우 수술 전 최소 1주 동안은 이 약 투여를 중단한다. 주요 수술 후 최소 2주가 지나 상처가 적절히 회복할 때까지 이 약을 투여하지 않는다.

상처 치유 지연으로 인한 합병증 회복 후 이 약을 다시 투여할 때의 안전성은 확인한 바 없다.

5) 임부, 수유부, 가임 여성 및 남성

동물시험 결과에 따르면, 이 약은 임부 투여 시 태아에 위해를 끼칠 수 있다(‘6. 임부, 수유부, 가임 여성 및 남성에 대한 투여’ 및 ‘13. 전문가를 위한 정보 4) 독성시험 정보’ 참조).

따라서, 임부에게 이 약의 태아에 대한 잠재적 위험성을 알려야 하며, 여성에게 이 약을 투여하는 동안 임신을 피하도록 권고한다. 가임 여성 및 가임 여성과 성관계를 갖는 남성은 이 약의 투여 기간과 마지막 투여 후 최소 1주일 동안 효과적인 피임법을 사용해야 한다.

이 약이 호르몬성 피임제에 미치는 영향 연구는 수행하지 않았다. 전신 호르몬성 피임제를 사용하는 경우, 차단 피임법을 추가로 사용해야 한다.

3. 이상반응

이 약의 안전성은 이전에 이매티닙, 수니티닙 및 레고라페닙을 포함하여 최소 3차 이상의 치료 받았으나 치료에 실패한 위장관기질종양 환자 128명을 대상으로 한 무작위배정 이중눈가림 위약 대조 임상시험(INVICTUS)에서 평가하였다. 환자 중 85명은 이 약 1일 1회 150 mg을 투여받았고 43명은 위약을 투여받았다. 이 약을 투여한 환자의 46%는 6개월 이상, 3.5%는 1년을 초과하여 투여받았다.

중대한 이상반응은 이 약을 투여한 환자의 31%에서 발생하였다. 이 중 2%를 초과하여 발생한 중대한 이상반응은 복통(4.7%), 빈혈(3.5%), 구역(2.4%) 및 구토(2.4%)였다.

이상반응으로 인해 이 약의 투여를 영구 중단한 환자는 8%였고, 영구 중단을 초래한 1% 이상 발생한 이상반응은 전신 건강 상태 악화(2.4%), 빈혈(1.2%), 심부전(1.2%), 손바닥 ‑발바닥 홍반성 감각 이상 증후군(1.2%) 및 구토(1.2%)였다.

이상반응으로 인해 이 약의 투여를 일시 중단한 환자는 24%였다. 투여 일시 중단을 초래한 2% 이상 발생한 이상반응은 구역(3.5%), 혈액 빌리루빈 증가(2.4%) 및 손바닥 ‑발바닥 홍반성 감각 이상 증후군(2.4%)이었다.

이상반응으로 인해 이 약을 감량한 환자는 7%였다. 용량 감량을 초래한 1% 이상 발생한 이상반응은 복통(1.2%), 초조(1.2%), 탈모(1.2%), 관절염(1.2%), 피부병(1.2%), 위장관 장애(1.2%), 감각 과민(1.2%), 근육통(1.2%), 손바닥 ‑발바닥 홍반성 감각 이상 증후군(1.2%) 및 체중 감소(1.2%)였다.

가장 흔한 이상반응( ≧20%)은 탈모, 피로, 구역, 복통, 변비, 근육통, 설사, 식욕 감소, 손바닥 ‑발바닥 홍반성 감각 이상 증후군 및 구토였다. 임상시험 INVICTUS에서 발생한 이상반응을 요약하였다(표2).

표 2. INVICTUS 시험에서 이 약을 투여한 위장관기질종양 환자 중 ≧10%에서 발생한 이상반응

이상반응	이 약 (N=85)		위약 (N=43)
이상반응	1-4 등급(%)	3-4등급(%)	1-4 등급(%)	3-4등급(%)
피부 및 피하 조직 장애
탈모	52	0	4.7	0
손바닥-발바닥 홍반성 감각 이상 증후군	21	0	0	0
건성 피부	13	0	7	0
소양증	11	0	4.7	0
전신 장애 및 투여 부위 병태
피로	42	3.5	23	2.3
말초 부종	17	1.2	7	0
무력증	13	1.2	14	4.7
위장관 장애
구역	39	3.5	12	0
복통	36	7	30	4.7
변비	34	1.2	19	0
설사	28	1.2	14	2.3
구토	21	3.5	7	0
구내염	11	0	0	0
근골격 및 결합 조직 장애
근육통	32	1.2	12	0
관절통	18	0	4.7	0
근육 연축	15	0	4.7	0
대사 및 영양 장애
식욕 감소	27	1.2	21	2.3
임상 검사
체중 감소	19	0	12	0
각종 신경계 장애
두통	19	0	4.7	0
각종 혈관 장애
고혈압	14	7	4.7	0
호흡기, 흉곽 및 종격 장애
호흡 곤란	13	0	0	0

가장 흔하게 발생한 3 ‑4등급 임상 검사치 이상( ≧4%)은 리파아제 증가 및 인산염 감소였다.

INVICTUS 시험에서 발생한 임상 검사치를 요약하였다(표3).

표 3. INVICTUS 시험에서 이 약을 투여한 위장관기질종양 환자군에서 위약군 대비 높은 빈도(>5%)로 나타나고, 기저치 대비 악화된( ≧10%) 임상 검사치 이상 항목

임상 검사치 이상	이 약^a (N=85)		위약^a (N=43)
임상 검사치 이상	1-4 등급(%)	3-4등급(%)^b	1-4 등급(%)	3-4등급(%)
혈액학 검사
활성화 부분 트롬보플라스틴 시간 연장	35	0	9	0
INR 증가	21	3.8	15	0
중성구 수 감소	10	0	2.5	0
화학 검사
리파아제 증가	32	7	13	8
인산염 감소	26	4.9	2.5	0
칼슘 감소	23	0	8	0
혈액 빌리루빈 증가	22	0	5	2.5
CPK 증가	21	1.2	10	0
나트륨 감소	17	2.4	10	2.5
혈청 아밀라아제 증가	13	1.2	5	0
ALT 증가	12	1.2	5	0
INR=국제 표준화 비율; CPK=크레아틴 인산 활성 효소; ALT=알라닌 아미노 전이 효소 ^a 빈도 계산시 사용한 분모는 기저치 값과 최소 1회 치료 후 임상 검사치 값이 있는 환자 수를 기준으로 하였으며, 이 약 투여군은 82-83명, 위약군은 34-40명으로 항목마다 상이하였다. ^b 3등급 임상검사치 이상만 포함하였다.

기타 이상반응

INVICTUS 시험에서 이 약을 투여한 환자에서 임상적으로 관련 있는 10% 미만 발생한 이상반응은 말초 감각 신경 병증, 여드름양 피부염 및 발진이었다.

4. 일반적 주의

1) 손바닥 ‑발바닥 홍반성 감각 이상 증후군

임상시험에서 이 약을 투여한 환자 중 손바닥 ‑발바닥 홍반성 감각 이상 증후군이 나타났다(사용상의 주의사항 ‘3. 이상반응’ 참조).

이상반응 중증도에 따라 이 약 투여를 일시 중단하고, 이후 동일한 용량 또는 감량한 용량으로 투여를 다시 시작한다(용법용량 ‘3) 이상반응에 따른 용량 조절’ 참조).

2) 광과민성

이 약은 광과민성을 유발할 가능성이 있다. 따라서, 이 약 투여 기간과 투여 중단 후 최소 1주 동안은 햇빛이나 자외선에 직접적인 노출을 피한다. 모자나 긴소매 옷과 같은 보호용 의복과 자외선차단제를 사용한다(사용상의 주의사항 ‘13. 전문가를 위한 정보 4) 독성시험 정보’ 참조).

3) 운전 및 기계 조작 능력 영향

이 약이 운전 및 기계 조작 능력에 미치는 영향은 평가한 바 없다. 이 약 투여 시 피로가 나타날 수 있으므로 이 약을 투여받는 환자는 운전 또는 기계 조작 시 주의를 기울여야 한다.

5. 상호작용

1) 강력한 시토크롬P450 3A(CYP3A) 억제제

이 약을 강력한 CYP3A 억제제와 병용투여할 경우, 리프레티닙 및 활성 대사체(DP ‑5439)의 노출이 증가하여 이상반응 발생 위험을 높일 수 있다.

병용 중에는 환자의 임상적 반응 및 내약성을 면밀히 모니터링해야 한다(사용상의 주의사항 ‘13. 전문가를 위한 정보 2) 약동학적 정보’ 참조).

2) 강력한 또는 중등도 시토크롬P450 3A(CYP3A) 유도제

이 약은 강력한 또는 중등도 CYP3A 유도제와 병용투여 하지 않는다.

이 약을 강력한 또는 중등도 CYP3A 유도제와 병용투여할 경우, 리프레티닙 및 활성 대사체(DP ‑5439)의 노출이 감소하여 이 약의 항종양 활성을 저하시킬 가능성이 있다(사용상의 주의사항 ‘13. 전문가를 위한 정보 2) 약동학적 정보’ 참조).

다만 병용투여가 불가피한 경우, 이 약을 1회 150mg, 1일 2회로 증량한다. 환자의 임상적 반응 및 내약성을 면밀히 모니터링 해야 한다. (용법용량 ‘4) 강력한 또는 중등도 CYP3A 유도제와 병용 시 용량 조절’ 참조).

6. 임부, 수유부, 가임 여성 및 남성에 대한 투여

(사용상의 주의사항 ‘13. 전문가를 위한 정보 1) 약리작용 정보 및 4) 독성시험 정보’ 참조).

1) 임부

동물시험 결과 및 작용기전에 근거할 때, 이 약을 임부에 투여하면 태아에 위해를 일으킬 수 있다. 현재 임부에서 이 약 사용에 따른 약물 관련 위험성을 평가한 자료는 없다.

따라서, 임부에게 이 약으로 인한 태아에 대한 잠재적 위험성을 알려야 한다.

2) 수유부

이 약이 모유로 이행하는지 또는 모유 수유 중인 영아나 모유 생산에 미치는 영향에 대한 자료는 없다. 그러나 모유 수유 중인 영아에서 중대한 이상반응이 발생할 가능성이 있으므로, 이 약의 투여 기간과 마지막 투여 후 최소 1주일 동안 모유 수유를 하지 않도록 권고한다.

3) 가임 여성 및 남성

⓵ 임신 검사

이 약의 투여 시작 전 가임 여성의 임신 여부를 확인한다.

⓶ 피임

가임 여성은 이 약의 투여 기간과 마지막 투여 후 최소 1주일 동안 효과적인 피임법을 사용할 것을 권고한다. 가임 여성과 성관계를 갖는 남성은 이 약의 투여 기간과 마지막 투여 후 최소 1주일 동안 효과적인 피임법을 사용할 것을 권고한다.

⓷ 불임

동물시험 결과에 근거할 때, 이 약은 가임 남성의 생식능에 영향을 미칠 수 있다.

7. 소아에 대한 투여

18세 미만 소아에서 이 약의 안전성 및 유효성은 확립되지 않았다.

8. 고령자에 대한 투여

INVICTUS 시험에서 이 약 1일 1회 150mg을 경구 투여받은 85명의 환자 중 65 ‑74세는 24%였고, 75세 이상은 9%였다. 65세 이상 고령자에 대한 투여 정보는 제한적이다.

9. 간장애 환자에 대한 투여

간장애 환자(Child ‑Pugh A, B 또는 C)에서는 용량 조절을 권장하지 않는다(사용상의 주의사항 ‘13. 전문가를 위한 정보 2) 약동학적 정보’ 참조).

10. 신장애 환자에 대한 투여

경증 ‑중등증 신장애 환자(Cockcroft ‑Gault 추정 CLcr 30 ‑<90mL/min)에서는 용량 조절을 권장하지 않는다. 중증 신장애 환자에 대한 연구는 수행하지 않았다(사용상의 주의사항 ‘13. 전문가를 위한 정보 2) 약동학적 정보’ 참조).

11. 과량투여 시의 처치

과량투여 시 이상반응의 징후 및 증상에 대해 면밀하게 모니터링하고, 필요한 경우 적절한 치료를 시작한다.

12. 보관 및 취급상의 주의사항

1) 반드시 원래 용기에 담아 보관한다.

2) 습기와 빛으로부터 보호하기 위하여 제습제가 들어있는 원래 용기에서 보관하며, 사용 후 제습제를 버리지 않는다.

13. 전문가를 위한 정보

1) 약리작용 정보

⓵ 작용기전

리프레티닙은 원암유전자(proto ‑oncogene) 수용체 티로신키나아제(KIT) 및 혈소판 ‑유래 성장 인자 수용체 A(PDGFRA) 키나아제(야생형, 원발성 및 이차 변이 포함)를 억제하는 티로신키나아제 억제제이다. 또한, 리프레티닙은 시험관 내(in vitro)에서 PDGFRB, TIE2, VEGFR2 및 BRAF와 같은 다른 키나아제도 억제했다.

⓶ 약력학

노출 ‑반응 관계

리프레티닙의 노출 ‑반응 관계 및 약력학적 시간 경과는 완전히 밝혀지지 않았다.

심장 전기생리학

이 약을 권장용량인 1일 1회 150mg 경구 투여 시 QTc 간격의 평균 증가(즉, >20ms)는 나타나지 않았다.

2) 약동학적 정보

임상시험에서 리프레티닙 및 그와 동등한 활성을 가진 대사체(DP ‑5439)의 약물 동태에 대해 분석하였다.

진행성 악성종양 환자에게 이 약 1일 1회 150mg을 경구 투여한 후 리프레티닙과 DP ‑5439의 Cmax,ss(CV%)는 각각 761ng/mL(31.8%), 804ng/mL(45.5%)이었고, AUC0 ‑12h,ss(CV%)은 각각 5678ng ◦h/mL(32.1%), 7138ng ◦h/mL(44.4%)이었다. 제1주기 15일차 추정 축적비는 리프레티닙이 1.7, DP ‑5439가 5.29였다. 리프레티닙, DP ‑5439 모두 14일 이내에 항정상태에 도달하였다.

⓵ 흡수

진행성 악성 종양 환자에게 이 약 150mg을 단회 경구 투여한 후 최고 혈장농도 도달 시간(Tmax) 중앙값(범위)은 리프레티닙이 4.02(1.95 ‑24.1)시간, DP ‑5439가 15.6(4.00 ‑24.8)시간이었다.

이 약을 고지방 식사(단백질 150, 탄수화물 250, 지방 500 ‑600칼로리)와 함께 투여한 경우, Cmax 및 AUC0 ‑24h에 임상적으로 유의한 변화는 나타나지 않았다.

⓶ 분포

시험관 내(in vitro) 시험 결과, 리프레티닙과 DP ‑5439는 99% 이상 사람 혈장 단백질 결합률을 나타낸다.

건강한 성인에게 이 약 150mg을 단회 경구 투여한 후 항정상태 겉보기 분포용적(Vss/F(CV%))은 리프레티닙이 307L(38.6%), DP ‑5439가 507L(50.5%)이었다.

⓷ 대사

리프레티닙과 DP ‑5439의 주요 대사 경로는 CYP3A4이다.

리프레티닙의 기타 대사 경로는 CYP2C8, CYP2D6이며, DP ‑5439의 기타 대사 경로는 CYP2C8, CYP2E1, CYP2D6이다.

⓸ 제거

건강한 성인에게 이 약 150mg을 단회 경구 투여한 후 겉보기 청소율(CL/F(CV%))은 리프레티닙이 15.3L/hr(45.2%), DP ‑5439가 17.5L/hr(62.7%)이었고, 반감기(t1/2(CV%))는 리프레티닙이 14.8시간(30.3%), DP ‑5439가 17.8시간(23.3%)이었다.

⓹ 배설

건강한 성인에게 이 약 50mg을 단회 경구 투여시 리프레티닙으로서 대변 34.2%, 소변 0.02%, DP ‑5439로서 대변 5.91%, 소변 0.10%로 배설되었다.

➅ 선형성/비선형성

진행성 악성 종양 환자에서 리프레티닙의 AUC0 ‑24h는 20 ‑250mg(권장용량의 0.13 ‑1.67배) 범위에서 용량에 비례하여 증가하였으나, Cmax는 용량에 비례하지 않았다. DP ‑5439의 Cmax 및 AUC0 ‑24h는 50 ‑250 mg(권장용량의 0.33 ‑1.67배) 범위에서 용량에 비례하지 않았다.

⑦ 특수 환자군

리프레티닙의 약물 동태는 연령(19 ‑87세), 성별, 인종(백인, 흑인 및 아시아인), 체중(39 ‑138kg), 종양 유형(GIST 또는 기타 고형암), 위절제술 여부, 경증 ‑중등증 신장애(Cockcroft ‑Gault 추정 CLcr 30 ‑<90mL/min) 및 경증 간장애(총 빌리루빈 ≦ULN 및 AST >ULN 또는 총 빌리루빈 1 ‑1.5 × ULN 및 AST 무관)에 따라 임상적으로 유의한 차이가 없었다.

중증 신장애 환자(CLcr 15 ‑29mL/min)에 대한 리프레티닙의 약물 동태를 평가한 연구는 수행하지 않았다.

간장애 환자

경증 간장애 환자에서 이 약 투여 시, AUC0 ‑last 및 Cmax에서 임상적으로 유의한 변화가 없었다.

중등증 간장애 환자에서 이 약 투여 시, 리프레티닙의 AUC0 ‑last가 2배 증가하였으나 Cmax는 변하지 않았으며 리프레티닙과 DP ‑5439의 합산 AUC0 ‑last는 1.5배 증가하였다.

중증 간장애 환자에서 이 약 투여 시, 리프레티닙의 AUC0 ‑last가 2.6배 증가하고 Cmax는 24% 감소하였으며, 리프레티닙과 DP ‑5439의 합산 AUC0 ‑last는 1.4배 증가하였다.

간장애 환자에서 확인한 리프레티닙의 노출 및 리프레티닙과 DP ‑5439의 합산 노출은 증가했으나, 이는 리프레티닙의 기존 안전성 프로파일에 근거할 때 임상적으로 유의하지 않다.

⑧ 약물 상호작용

CYP 효소

임상시험에서 CYP2C8의 민감한 기질인 레파글리나이드와 병용투여 시, 레파글리나이드의 약동학적 특성은 임상적으로 유의한 차이를 보이지 않았다.

리프레티닙 및 DP ‑5439는 CYP1A2, CYP3A4의 유도제가 아니다.

시험관 내(in vitro) 시험에서 리프레티닙 및 DP ‑5439는 CYP2B6를 유도하였다. 리프레티닙을 치료역이 좁은 CYP2B6 기질 약물(예: efavirenz)과 병용투여 시 해당 약물의 효능을 감소시킬 수 있다.

강력한 CYP3A 억제제

임상시험에서 강력한 CYP3A 억제제이자 P ‑gp 억제제인 이트라코나졸과 병용투여 시, 리프레티닙의 Cmax는 36% 증가하였고, AUC0 ‑inf는 99% 증가하였다. 또한, DP ‑5439의 AUC0 ‑inf도 99% 증가하였으나 Cmax는 변하지 않았다.

강력한 CYP3A 유도제

임상시험에서 강력한 CYP3A 유도제인 리팜핀과 병용투여 시, 리프레티닙의 Cmax는 18% 감소하였고, AUC0 ‑inf는 61% 감소하였다. 또한, DP ‑5439의 AUC0 ‑inf는 57% 감소하였으나 Cmax는 37% 증가하였다.

중등도 CYP3A 유도제

생리학 기반 약동학(PBPK) 모델링에서 중등도 CYP3A 유도제인 에파비렌즈와 병용투여 시, 리프레티닙의 Cmax는 24% 감소하고, AUC0 ‑inf는 56% 감소할 것으로 예측하였다.

프로톤 펌프 억제제

임상시험에서 프로톤 펌프 억제제인 판토프라졸과 병용투여 시, 리프레티닙 및 DP ‑5439의 혈장 노출은 임상적으로 유의한 차이를 보이지 않았다.

수송체 시스템

리프레티닙 및 DP ‑5439는 P ‑당단백질(P ‑gp) 및 유방암내성단백질(BCRP)의 기질이다. 리프레티닙은 P ‑gp 및 BCRP 억제제이며, DP ‑5439는 BCRP 및 다중약물 ▪독소배출단백질 1(MATE1) 억제제이다.

UGT1A 기질 약물

리프레티닙은 UGT1A1, UGT1A3, UGT1A4, UGT1A7 및 UGT1A8의 억제제이다.

3) 임상시험

다국가, 다기관, 무작위배정(2:1), 이중눈가림, 위약대조 임상시험인 INVICTUS에서 이 약의 유효성을 평가하였다. 대상 환자는 절제 불가능한 국소 진행성 또는 전이성 위장관기질종양(GIST) 환자로, 이매티닙, 수니티닙 및 레고라페닙으로 치료 받은 경험이 있어야 했다.

무작위배정은 이전 치료 차수(3차 vs 4차 이상) 및 미국 동부 종양학 협력기구(ECOG) 수행능력 상태(0 vs 1 또는 2)에 따라 층화했다. 환자는 이 약 150mg 또는 위약을 1일 1회 경구 투여받았으며, 질병 진행 또는 수용할 수 없는 독성이 나타날 때까지 치료를 지속하였다. 종양 반응 평가는 첫 4개월 동안은 28일마다, 이후에는 56일마다 시행하였다.

주요 유효성 평가변수는 mRECIST 1.1 기준에 따른 눈가림 독립중앙평가(BICR)에 의한 무진행 생존(PFS)이었다. 이때 림프절 및 골 병변은 대상 병변에서 제외했으며, 기존 종양 내에서 점진적으로 성장하는 새로운 종양 결절은 특정 기준을 충족해야만 명백한 진행으로 판단했다. 추가 유효성 평가변수는 BICR에 따른 객관적 반응률(ORR) 및 전체 생존(OS)이었다. 위약군에 무작위배정 받은 환자는 질병 진행 시 이 약으로 치료 받을 수 있었다.

총 129명의 환자를 시험군 85명과 위약군 44명으로 무작위배정하였다. INVICTUS 시험에서 치료의도군(Intention ‑to ‑Treat, ITT) 환자 특성은 다음과 같다. 환자의 연령 중앙값은 60세(범위: 29 ‑83세)였으며, 39%가 65세 이상이었다. 57%는 남성이었고, 75%는 백인이었으며, 92%는 ECOG 수행능력 상태가 0 또는 1이었다. 환자의 63%는 3차 치료까지, 37%는 4차 이상 치료를 받은 경험이 있었다. 위약군에 무작위배정 받은 환자의 66%는 질병 진행 후 이 약으로 전환하였다.

INVICTUS 시험의 유효성 결과는 표 4에 요약하였다.

표 4. INVICTUS 시험의 유효성 결과

	이 약 (N=85)	위약 (N=44)
무진행 생존^a
사례 수(%)	51 (60)	37 (84)
질병 진행	46 (54)	32 (73)
사망	5 (6)	5 (11)
PFS 중간값, 개월(95% CI)	6.3 (4.6, 6.9)	1.0 (0.9, 1.7)
HR(95% CI)^c	0.15 (0.09, 0.25)
p-값^b	< 0.0001
객관적 반응률^a
ORR(95% CI)	9 (4.2, 18)	0 (0, 8)
p-값^d	0.0504
전체 생존^e
사망 수(%)	26 (31)	26 (59)
OS 중간값, 개월(95% CI)	15.1 (12.3, 15.1)	6.6 (4.1, 11.6)
HR(95% CI)^c	0.36 (0.21, 0.62)
PFS = 무진행 생존기간; CI = 신뢰구간; HR = 위험비; ORR = 객관적 반응률; OS = 전체 생존기간; BICR = 눈가림 독립중앙평가 ^a 눈가림 독립중앙평가(Blinded Independent Central Review, BICR). ^b p-값은 양측 층화 로그-순위 검정(2-sided stratified log-rank test)을 기반으로 함. ^c 위험비(hazard ratio)는 Cox 비례위험 회귀모형에 기반함. 해당 모형은 치료군과 무작위배정 층화인자를 고정 요인으로 포함함. ^d Fisher의 정확 검정을 기반으로 함. p-값은 통계적으로 유의하지 않음. ^e 2차 평가변수인 ORR 및 OS에 대한 순차적 검정 절차의 결과로, 통계적 유의성에 대해 평가하지 않음.

그림 1. INVICTUS 시험에서 무진행 생존에 대한 Kaplan ‑Meier 곡선<IMG 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">

그림 2. INVICTUS 시험에서 전체 생존에 대한 Kaplan ‑Meier 곡선<IMG 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

의약품 정보

금지약물 여부

금지목록 국제표준 분류

경기기간 중 금지약물 사용 시 주의사항

주사제 사용 시 주의사항

검색하신 약물 및 방법이 금지약물 또는 방법에 해당하나요?

효능 · 효과

용법 · 용량

사용상의 주의사항

복약정보

금지약물 정보

분류제목

KPIC 의약품 상세 정보