의약품 상세정보 표입니다.
제품명	와이누아오토인젝터주45mg [Wainua Auto-Injector Inj. 45mg]
성분 / 함량	Eplontersen Sodium 에플론테르센나트륨 47mg/0.8mL
전문 / 일반	전문(희귀)
단일 / 복합	단일
제조 / 수입사	한국아스트라제네카
제형	주사제
투여경로	주사
성상	무색 내지 황색의 용액이 들어있는 프리필드시린지가 오토인젝터에 장착된 주사제
허가일	허가일: 2026년 07월 10일
대조 / 생동
급여정보	Onetwo0825O
ATC코드	N07XX21 : eplontersen
KPIC 약효분류
제품설명서
포장단위 (식약처 기준)	1오토인젝터/상자[오토인젝터(0.8밀리리터)]
저장방법	밀봉용기, 차광하여 냉장(2~8℃) 보관

용법 · 용량

이 약은 아밀로이드증 환자 관리에 대해 지식이 있는 진료의가 처방과 감독을 해야 한다.

1) 용량

이 약의 권장 용량은 45 밀리그램이며, 월 1회 피하주사한다.

이 약으로 치료를 받는 환자에게 1일 권장섭취량의 비타민 A 보충을 권장한다(사용상의주의사항 1. 경고 참조).

3단계 다발신경병증으로 진행된 환자의 치료를 계속할지 여부는 전반적인 유익성과 위해성 평가를 바탕으로 의사의 판단에 따른다.

투여를 놓친 경우

이 약의 투여를 놓친 경우, 가능한 한 빨리 다음 용량을 투여해야 한다. 마지막 투여일로부터 한 달 간격으로 투여를 다시 시작하도록 한다.

2) 용법

이 약은 피하로만 투여한다.

환자 또는 간병인이 처음 주사하는 경우, 적절한 자격을 갖춘 의료전문가의 지도하에 실시해야 한다. 환자 및/또는 간병인은 이 약의 피하주사에 대한 교육을 받아야 한다(사용상의주의사항 10. 적용상의 주의 참조).

사용상의 주의사항

1. 경고

혈청 비타민 A 수치 감소

이 약은 혈청 비타민 A 수치를 감소시킨다(12. 전문가를 위한 정보 1) 약리작용 참조).

이 약 투여를 시작하기 전에 비타민 A 결핍과 관련된 모든 증상 또는 징후를 평가해야 한다.

이 약을 투여받는 환자는 비타민 A 결핍으로 인한 안구 증상의 잠재적 위험을 줄이기 위해 1일 권장섭취량의 비타민 A를 경구 복용해야 한다. 핵심 임상시험에서, 모든 피험자는 시험약과 더불어 비타민 A의 1일 권장섭취량에 해당하는 용량(비타민 A 약 3,000 IU 또는 시험대상자가 거주하는 지역에서 확보 가능한 가장 근접한 용량)을 복용하였다. 환자에게 야간 시력 저하, 야맹증 및 지속적인 안구 건조 등의 비타민 A 결핍과 일치하는 안구 증상이 나타나는 경우, 안과 검사를 권장한다.

임부가 이 약을 계속 투여하는 경우, 임신 중 비타민 A를 보충하는 것이 이 약으로 인한 비타민 A 결핍을 예방하기에 충분한지는 알려져 있지 않다(5. 임신, 수유 및 가임 여성 참조). 그러나, 임신 중 비타민 A 보충을 1일 권장섭취량 이상으로 늘리면, 이 약의 작용 기전을 고려할 때, 혈청 비타민 A 수치가 보정될 가능성은 낮으며 산모와 태아에게 해로울 수 있다.

2. 다음 환자에는 투여하지 말 것

이 약의 활성 물질이나 첨가제에 중증 과민증(예: 아나필락시스)이 있는 환자에게는 투여해서는 안 된다.

3. 약물이상반응

1) 전반적인 안전성 프로파일 요약

아래에 기술된 안전성 프로파일은 무작위배정으로 이 약을 최소 1회 이상 투여받은 트랜스티레틴 가족성 아밀로이드성 다발신경병증(ATTRv ‑PN) 환자 144명의 자료이다. 이들 중, 141명은 최소 6개월간 투여 받았고, 137명은 최소 12개월간 투여 받았다. 투여 지속 기간의 평균값은 541일(범위: 57일~582일)이었다.

이 약 투여 중 관찰된 가장 흔한 약물이상반응은 구토와 비타민 A 감소로, 전체 환자의 5% 이상에서 나타났다.

2) 약물이상반응

MedDRA 기관계 대분류(SOC)에 따라 약물이상반응을 분류하였다. 약물이상반응의 발생 빈도는 다음과 같이 정의된다: 매우 흔하게( ≧1/10); 흔하게( ≧1/100~<1/10); 흔하지 않게( ≧1/1,000~<1/100); 드물게( ≧1/10,000~<1/1000); 매우 드물게(<1/10,000)

표 1. 빈도 범주별 약물이상반응 요약

기관계 대분류	약물이상반응	빈도
위장관 장애	구토	흔하게
전신 장애 및 투여 부위 병태	주사 부위 홍반	흔하게
	주사 부위 통증	흔하게
	주사 부위 소양증	흔하게
검사	비타민 A 감소	매우 흔하게

3) 일부 약물이상반응에 대한 설명

⓵ 비타민 A 감소

NEURO ‑TTRansform 연구에서, 모든 환자는 비타민 A 1일 권장섭취량을 복용하였다. 이 약을 투여 받은 모든 환자는 베이스라인 시점에 비타민 A 수치가 정상이었으며, 이들 중 96.5%는 시험 동안 비타민 A 수치가 정상 하한(LLN) 미만으로 감소하였다(12. 전문가를 위한 정보 1) 약리작용 참조).

⓶ 주사 부위 반응

NEURO ‑TTRansform 연구에서, 주사부위의 홍반, 통증 및 소양증이 각각 3.5%, 3.5% 및 2.1%에서 보고되었다.

4. 약물 상호작용

약물 간 상호작용을 평가하기 위한 임상시험은 수행하지 않았다(12. 전문가를 위한 정보 2) 약동학적 정보 참조).

5. 임신, 수유부 및 가임 여성

1) 가임 여성

이 약은 정상적인 태아 발달에 매우 중요한 비타민 A의 혈장 수치를 감소시킨다. 비타민 A 보충이 태아에 대한 위험을 줄이기에 충분한지는 알려져 있지 않다. 따라서 임부에게는 투여하지 않아야하며, 가임기 여성은 효과적인 피임법을 이용해야 한다.

임신을 계획하고 있는 여성의 경우, 이 약과 비타민 A 보충제를 중단해야 하며, 혈청 비타민 A 수치를 모니터링하고 임신을 시도하기 전에 정상치로 돌아온 것을 확인해야 한다. 이 약의 반감기가 길어(12. 전문가를 위한 정보 2) 약동학적 정보 참조), 투여 중단 후에도 비타민 A 결핍이 발생할 수 있다.

2) 임부

임부에게 투여 시 이 약에 대한 안전성 ▪유효성은 확립되지 않았다(이용가능한 자료가 없다).

마우스를 대상으로 한 생식능력 및 배 ▪태자 발달 통합 독성시험에서 이 약 또는 설치류에서 약리학적 활성을 나타내는 특이 대리체를 인체 권장량보다 최대 38배 높은 용량으로 투여한 결과, 수컷 및 암컷의 생식능력 또는 배 ▪태자발달에 영향을 미치지 않았다(12. 전문가를 위한 정보 4) 비임상 안전성 자료 참조).

불균형한 비타민 A 수치로 잠재적인 기형 발생 위험이 있으므로, 이 약을 임신 중에 사용해서는 안 된다. 임신했을 경우, 특히 임신 초기에는 태아와 비타민 A 상태를 면밀히 모니터링해야 한다.

3) 수유부

모유 내 이 약이나 대사체의 존재, 모유 수유를 받는 유아에 미치는 영향 또는 산모의 모유 생산에 미치는 영향을 평가하기 위한 사람 또는 동물 수유 연구는 수행하지 않았다. 모유 수유를 받는 유아에 대한 위해성을 배제할 수는 없다. 모유 수유가 주는 이점과 산모에게 해당 요법이 주는 이점을 고려하여 모유 수유를 중단할지 또는 이 약 요법을 중단할지 여부를 결정해야 한다.

4) 수태능

이 약이 사람의 생식능에 미치는 영향은 알려져 있지 않다.

마우스를 대상으로 이 약 또는 설치류에서 약리학적 활성을 나타내는 특이 대리체를 인체 권장 노출량보다 최대 38배 높은 용량으로 투여한 결과, 이 약이 수컷 및 암컷의 생식능력에 영향을 미치지 않는 것을 확인하였다.

6. 소아에 대한 투여

18세 미만 소아에 대한 이 약의 안전성과 유효성은 확립되지 않았다.(이용 가능한 자료가 없다.)

7. 고령자에 대한 투여

65세 이상 환자의 경우 용량 조절이 필요하지 않다(12. 전문가를 위한 정보 2) 약동학적 정보 참조).

8. 신장애 및 간장애 환자에 대한 투여

1) 신장애

경증에서 중등증 신장애 환자(추정 사구체 여과율 [eGFR] ≧45 ~ <90 mL/min/1.73m2)에게는 용량 조절이 필요하지 않다. 이 약은 eGFR<45 mL/min/1.73m2 또는 말기 신장질환 환자 대상으로 이용 가능한 자료는 없다.

2) 간장애

경증 간장애 환자에서 이 약의 용량 조절은 필요하지 않다. 중등증 또는 중증 간장애가 있는 환자 및 간 이식 환자에서 이 약의 안전성 ▪유효성은 확립되지 않았다.

9. 과량투여시의 처치

이 약을 과량투여 했을 때 특별한 치료법은 없다. 과량투여 시, 의사의 진료를 받고 보조적인 의학적 치료를 제공해야 한다.

10. 적용상의 주의

<오토인젝터를 이용한 주사 준비>

1) 주사에 필요한 준비물 준비

냉장고에서 꺼낸 상자 안의 오토인젝터 1개

미포함

2) 30 분 기다리기

주사하기 전에, 오토인젝터를 상자에 넣은 상태로 실온 20 ℃ - 25 ℃ 에서 30분간 둔다.

· 전자레인지, 뜨거운 물, 또는 다른 열원을 사용하여 데워서는 안된다.

· 빛 또는 직사광선을 피한다.

3) ① 상자에서 오토인젝터를 꺼내어 확인

오토인젝터의 손상 여부를 확인한다.

· 손상된 경우 사용하지 않는다.

· 사용기한(EXP)을 확인한다.

· 사용기한이 지난 경우 사용하지 않는다.

② 확인창을 통해 액체를 확인한다.

· 액체는 맑고 무색 또는 연한 노랑색이어야 한다.

· 액체 내에 작은 기포가 보이는 것은 정상적 상태이다.

· 액체가 혼탁하거나 변색되었거나, 눈에 보이는 입자가 있는 경우 사용하지 않는다.

<오토인젝터로 주사하기>

4) 주사 부위 선택

환자 또는 보호자는 허벅지 앞쪽 또는 복부의 아래쪽 부위에 주사할 수 있다.

보호자는 환자의 상완 뒤쪽 부위에 주사할 수 있으며,

환자가 상완 뒤쪽에 스스로 주사하지 않는다.

각 주사 시, 이전에 주사한 부위로부터 최소 1인치(3cm) 이상 떨어진 부위를 주사한다.

다음 부위에는 주사하지 않는다:

· 배꼽 주변 2인치(5cm) 범위

· 피부가 붉거나, 열감이 있거나, 압통이 있거나, 멍이 들었거나, ·각질이 있거나, 단단한 부위

· 흉터가 있는 부위, 손상된 피부, 변색된 피부 또는 문신이 있는 피부

· 옷 위

5) 손을 씻고 주사 부위를 소독

비누와 물로 손을 깨끗이 씻는다.

알코올 솜으로 주사 부위를 닦거나, 비누와 물로 주사 부위를 닦는다. 해당 부위가 자연 건조되도록 둔다.

주사하기 전에 소독한 부위를 만지지 않는다.

6) 캡을 뽑아 제거

한 손으로 본체를 잡고, 다른 손으로 조심스럽게 곧게 당겨 캡을 제거한다. 이제 주황색 바늘 보호대가 노출되며, 바늘은 그 아래에 숨겨져 있다.

· 캡은 폐기한다.

· 바늘을 만지거나, 손가락으로 주황색 바늘 보호대를 누르지 않는다.

· 본체를 다시 캡으로 덮지 않는다. 이는 약물이 너무 빨리 나올 수 있거나 오토인젝터를 손상시킬 수 있다.

7) 오토인젝터로 주사

그림 a, b, c, d의 단계에 따라 오토인젝터로 주사한다.

주사 시, 주황색 플런저가 확인창을 채울 때까지 10초 동안 펜을 누르고 유지한다. 주사 시작 시 첫 번째 ‘딸깍’ 소리, 주사 종료 시 두 번째 ‘딸깍’ 소리가 나며, 이는 정상이다.

주사가 시작된 후에는 오토인젝터를 움직이거나 위치를 변경해서는 안된다.

오토인젝터 위치 잡기

· 주황색 바늘 보호대를 피부에 평평하게 댄다(90도 각도).

· 확인창이 보이도록 한다.

아래로 단단히 누르고 유지

· 주사를 시작하면 즉시 첫 번째 ‘딸깍’ 소리가 나며, 이는 주사가 시작되었음을 의미한다.

· 주황색 플런저가 확인창에서 아래로 이동한다.

약 10초간 단단히 누른 상태로 유지

· 주황색 플런저가 확인창을 채운다.

· 주사 종료 시 두 번째 ‘딸깍’ 소리가 난다.

주사 완료 후 오토인젝터를 수직으로 들어 올리기

· 주황색 바늘 보호대가 아래로 내려가며 바늘 위를 덮고, 잠금 상태로 고정된다.

8) 확인창 확인

확인창을 확인하여 모든 약물이 주사되었는지 확인한다.

주황색 플런저 로드가 확인창을 완전히 채우지 않은 경우, 전체 용량을 투여받지 못했을 수 있다.

이러한 경우 또는 기타 우려사항이 있는 경우 의료전문가에게 문의한다.

사용전

사용후

9) 주사 부위 확인

주사 부위에서 소량의 혈액 또는 액체가 나올 수 있다. 이는 정상이다.

필요 시, 솜 또는 거즈로 해당 부위를 누르고 작은 밴드를 붙인다.

10) 사용한 오토인젝터 폐기

사용한 약을 천공 방지형(날카로운 물체용) 폐기용기에 넣는다.

사용한 약을 일반 생활쓰레기로 버리지 않는다.

11. 보관 및 취급상의 주의사항

1) 배합금기

본 제품을 다른 의약품과 혼합해서는 안 된다.

2) 보관 시 특별 주의사항

⓵ 얼리지 않아야 하며, 열에 노출되지 않도록 한다.

⓶ 2℃~ 8℃에서 냉장 보관하며, 빛으로부터 보호하기 위해 상자 그대로 보관한다.

⓷ 필요 시, 상자 그대로 30℃ 이하의 실온에서 최대 6주까지 보관할 수 있으며, 6주 이내에 사용하지 않을 경우 폐기해야한다.

12. 전문가를 위한 정보

1) 약리작용

작용 기전

이 약은 N ‑아세틸갈락토사민(GalNAc)이 접합된 2′ ‑O ‑2 ‑메톡시에틸(2′ ‑MOE) 변형 키메릭 갭머(gapmer) 형태의 안티센스 올리고뉴클레오티드(ASO)로서, 인산티오에이트(PS)와 인산디에스터(PO) 결합이 혼합된 골격을 가지고 있다. GalNAc 접합체는 ASO가 간세포에 표적 전달될 수 있도록 한다. 이 약이 간세포 내의 TTR 메신저 RNA(mRNA)에 선택적으로 결합하면 돌연변이형 및 야생형(정상) TTR mRNA를 모두 분해시킨다. 이는 간에서 TTR 단백질의 합성을 방해하여, 간에서 순환계로 분비되는 돌연변이형 및 야생형 TTR 단백질의 수준을 유의하게 감소시킨다.

약력학적 효과

NEURO ‑TTRansform 연구에서, 첫 평가(제5주) 시점에 혈청 TTR 농도 감소가 나타났으며, 제35주 시점까지 TTR 농도가 지속적으로 감소하였다. 투여 지속 기간(85주) 내내 TTR 농도의 지속적인 감소가 나타났다. 이 약을 투여하였을 때, 베이스라인 대비 혈청 TTR 감소율 평균(SD)은 제35주에 82.1%(11.7), 제65주에 83.0%(10.4), 제85주에 81.8%(13.4)로 나타났다. 베이스라인 시점에 성별, 인종, 나이, 지역, 체중, 심근병증 상태, 이전 치료, Val30Met 돌연변이 상태, 질병 단계 및 가족성 아밀로이드 심근병증(FAC) 임상 진단과 관계없이, 위약과 비교하여 혈청 TTR 농도의 베이스라인 대비 감소가 유사하게 나타났다.

TTR은 비타민 A(레티놀)의 주요 운반체인 레티놀 결합 단백질 4(RBP4)의 운반 단백질이다. 따라서, 혈장 TTR이 감소하는 경우 혈장 비타민 A 수치가 정상 하한치 미만으로 감소할 것으로 예상된다.

2) 약동학적 특성

건강한 대상자에게 단회 및 다회 용량(4주에 1회)으로 피하 투여하고, ATTRv ‑PN 환자를 대상으로 다회 용량(4주에 1회)으로 피하 투여한 후 이 약의 약동학적(PK) 특성을 평가하였다.

⓵ 흡수

피하 투여 후 이 약은 전신 순환으로 빠르게 흡수되며, 대략 2시간 후 최대 혈장 농도에 도달한다(집단 추정치 기준).

ATTRv ‑PN 환자에게 4주마다 45 mg을 1회 투여한 후 평형 상태 최대 농도(Cmax), 최저 농도(Ctrough) 및 곡선하 면적(AUCτ)의 집단 추정치는 각각 0.218 μg/mL, 0.000200 μg/mL 및 1.95 μg ▪h/mL이었다. 반복 투여(4주마다 1회) 후 혈장에서 이 약의 Cmax 및 AUC의 축적은 나타나지 않았다. Ctrough에서 축적이 나타났으며, 대략 17주 후에 평형 상태에 도달하였다.

⓶ 분포

동물실험(마우스, 랫드, 원숭이) 결과, 이 약은 피하주사 투여 후 주로 간과 신장 피질에 분포하는 것으로 나타났다. 이 약은 인간 혈장 단백질에 높은 결합력을 나타낸다(>98%). 겉보기 중심 분포용적(apparent central volume of distribution)에 대한 집단 추정치는 12.9 L이고 겉보기 말초 분포용적(apparent peripheral volume of distribution)은 11,100 L이다.

⓷ 생체내변환

이 약은 엔도뉴클레이스와 엑소뉴클레이스에 의해 간 내에서 다양한 크기의 짧은 올리고뉴클레오티드 분절로 대사된다. 인체에서 주요 순환 대사산물은 없었다. 이 약을 포함한 올리고뉴클레오티드 치료제는 보통 CYP 효소의 기질이 아니다.

⓸ 배설

이 약은 주로 대사를 통해 제거된 후 짧은 올리고뉴클레오티드 대사산물이 신장으로 배설된다. 24시간 이내에 소변으로 제거되는 변화되지 않은 ASO의 평균 분율은 투여된 용량의 1% 미만이었다. 집단 추정치를 기준으로 최종 소실 반감기는 약 3주이다.

⓹ 선형성/비 ‑선형성(Linearity/non ‑linearity)

건강한 지원자를 대상으로 이 약 45~120 mg(즉, 권장량의 1~2.7배)을 단회 피하주사 시 Cmax와 AUC는 용량 비례보다 약간 더 증가하였다.

➅ 특수 집단

집단 약동학 및 약력학 분석에 따르면, 체중, 성별, 인종 및 Val30Met 돌연변이 상태는 평형 상태에서의 이 약의 노출 또는 혈청 TTR 감소에 임상적으로 의미 있는 영향을 미치지 않는다. 대상자 수가 제한적이기 때문에, 일부 증례에서 확정적인 평가를 할 수 없다.

고령자 집단

성인과 고령 환자(65세 이상)에서 간 약동학은 전반적으로 차이가 나타나지 않았다.

신장애

이 약의 약동학에 신장애가 미치는 영향에 대한 연구는 수행되지 않았다. 집단 약동학 및 약력학 분석 결과, 경증 및 중등증 신장애(eGFR ≧45~<90 mL/min/1.73 m2)를 기준으로 이 약의 약동학 또는 약력학에 있어 임상적으로 유의미한 차이는 없었다. 이 약은 eGFR<45 mL/min/1.73m2 또는 말기 신장질환 환자를 대상으로 하여 연구한 바 없다.

간장애

이 약의 약동학에 간장애가 미치는 영향에 대한 연구는 수행되지 않았다. 집단 약동학 및 약력학 분석 결과, 경증 간장애(총 빌리루빈 ≦1 x ULN 및 AST >1 x ULN, 또는 총 빌리루빈 >1.0 ~ 1.5 x ULN 및 임의의 AST)를 기준으로 이 약의 약동학 또는 약력학에 있어 임상적으로 유의미한 차이는 없었다. 이 약은 중등증 또는 중증 간장애 환자 또는 이전에 간이식을 받은 환자를 대상으로 하여 연구한 바 없다.

⑦ 약물 ‑약물 상호작용

약물 상호작용 임상 연구는 수행되지 않았다. In vitro 시험 결과, 이 약은 수송체의 기질이나 억제제가 아니며, 혈장 단백질 결합도가 높은 약물과 상호작용하지 않고, CYP 효소의 억제제나 유도제도 아니다. 이 약을 포함한 올리고뉴클레오티드 치료제는 보통 CYP 효소의 기질이 아니다. 따라서, 이 약은 약물 수송체, 혈장 단백질 결합 또는 CYP 효소를 통해 매개되는 약물 ‑약물 상호작용을 일으키거나 이에 영향을 받지 않을 것으로 예상된다.

3) 임상시험 정보

⓵ 심장 전기생리학

이 약에 대해 공식적인 QTc 시험을 수행하지 않았다. 건강한 지원자를 대상으로 한 무작위배정, 위약 대조 임상시험에서 이 약의 QTc 연장 가능성을 평가하였다. 이 약의 권장 용량인 45mg의 2.7배 용량 투여 시, QT 간격에 대해 임상적으로 관련된 영향은 나타나지 않았다.

⓶ 면역원성

NEURO ‑TTRansform 연구에서, 84주 투여 기간(투여 지속 기간 중앙값 561일(80주), 범위: 57일~582일) 후 환자 58명(40.3%)에서 투여 후 발생한 항 ‑약물 항체(ADA)가 나타났다.

ADA 양성 반응을 보인 환자에서, 이 약의 유효성, 안전성, 약동학 또는 약력학에 대해 임상적으로 의미 있는 영향은 없었다.

⓷ 임상 유효성

무작위배정, 다기관, 공개, 외부 대조 임상시험(NEURO ‑TTRansform)을 통해 총 168명의 ATTRv ‑PN 환자를 대상으로 이 약의 유효성과 안전성을 평가하였다. 6:1의 비율로 환자를 무작위배정하여 4주마다 피하주사로 이 약 45mg(N=144)을 투여하거나 대조군으로 매주 이노테르센 284mg(N=24)을 투여하였다. 이 약에 무작위배정된 환자 144명 중, 140명(97.2%)이 제35주까지 투여를 완료하였고, 135명(93.8%)이 제65주까지, 그리고 130명(90.3%)이 제85주까지 투여를 완료하였다.

외부 위약군은 이노테르센 핵심 임상시험(ATTRv ‑PN 성인 환자를 대상으로 한 무작위배정. 이중 눈가림, 위약 대조, 다기관 임상시험(NEURO ‑TTR))의 위약 코호트 환자로 구성되었다. 해당 코호트는 위약을 주 1회 피하주사로 투여했으며, 두 시험 모두 동일한 적합성 기준을 이용하였다.

이 약과 외부 위약군의 특성은 전반적으로 유사하였으며, 주요 베이스라인 특성(Val30Met 돌연변이 상태, 질병 단계 및 이전 치료)의 잠재적 불균형은 사전에 지정된 통계 분석에서 고려되었다. 이 약에 무작위배정된 환자 144명에서, 베이스라인 시점의 연령 중앙값은 51.5세(범위: 24~82세)였고, 65세 이상 환자는 30.6%였고, 환자의 69.4%는 남성이었다. 총 20가지의 상이한 TTR 변이가 나타났으며, Val30Met(59.0%), Phe64Leu(3.5%), Leu58His(2.8%), Thr60Ala(2.8%), Val122Ile(2.8%), Ser77Tyr(2.1%), Ser50Arg(1.4%), Thr49Ala(0.7%), Glu89Gln(0.7%) 및 기타 (24.3%, Ala97Ser [15%] 포함)였다. 베이스라인 시점에서, 환자의 79.9%는 1기 질환(보행 장애 없음; 하지의 경도 감각성, 운동성 및 자율신경병증)이었고, 20.1%는 2기 질환(보행 시 도움이 필요함; 하지, 상지 및 체간의 중등도 기능장애)이었으며, 3기 질환 환자는 없었다. 또한, 환자의 69.4%는 이전에 타파미디스 또는 디플루니살로 치료 받은 적이 있었다.

제35주 분석

일차 유효성 평가변수는 베이스라인으로부터 제35주까지 혈청 트랜스티레틴(TTR) 농도 변화와 mNIS+7(modified Neuropathy Impairment Score + 7) 종합 점수 변화였다. 임상시험에서 사용된 mNIS+7 종합 점수는 NIS를 통해 뇌신경 기능, 근력, 반사 및 감각의 결함을 객관적으로 측정하였고, Modified +7을 통해 심호흡에 대한 심박수 반응, 정량적 감각 검사(촉각 ‑압력 및 열 ‑통증) 및 말초 신경 전기생리학을 평가하였다. 임상시험에 사용된 mNIS+7 종합 점수 범위는 ‑22.3점~346.3점이며, 점수가 더 높을수록 질환의 중증도가 더 크다는 것을 나타낸다.

이차 평가변수는 Norfolk 삶의 질 ‑ 당뇨병성 신경병증(Norfolk QoL ‑DN) 설문지 총점의 베이스라인 대비 변화였다. Norfolk QoL ‑DN 설문지에는 신체 기능/대섬유 신경병증, 일상 생활 활동, 증상, 소섬유 신경병증, 자율 신경병증과 관련된 영역이 포함되며, 총점 범위는 ‑4점부터 136점으로, 점수가 더 높을수록 삶의 질이 악화되고 있음을 나타낸다.

이 약은 제35주 시점에 혈청 TTR 감소에 있어 외부 위약군 대비 통계적으로 유의한 개선을 나타냈으며, 그 변화율은 ‑66.43%이었다(95% CI: ‑71.39%, ‑61.47%; p<0.0001)(표 2 및 그림 1 참조). 이 약은 제35주 시점에 mNIS+7 종합 점수에 있어 외부 위약군 대비 통계적으로 유의한 개선을 나타냈으며, LSM 차이는 ‑9.0이었다(95% CI: ‑13.5, ‑4.5; p<0.0001)(표 2 및 그림 2 참조). 이 약은 제35주 시점에 Norfolk QoL ‑DN 종합 점수에 있어 외부 위약군 대비 통계적으로 유의한 개선을 나타냈으며, LSM 차이는 ‑11.8이었다(95% CI: ‑16.8, ‑6.8; p<0.0001)(표 2 및 그림 3 참조).

제65주/제66주

제66주 분석에서 공동 일차 평가변수는 제65주 시점 혈청 TTR 농도의 베이스라인 대비 변화율, 제66주 시점 mNIS+7 종합 점수의 베이스라인 대비 변화율, 제66주 Norfolk QoL ‑DN 총점의 베이스라인 대비 변화율 등이었다. 제65주 시점에, 혈청 TTR 농도가 지속적으로 감소하였다. 또한, 제66주 시점의 mNIS+7 종합 점수 및 Norfolk 총점 결과는 모두 제35주 결과와 일치하였다(표 2 및 그림 1, 2, 3 참조).

표 2. 일차 및 주요 이차 평가변수에 대한 치료 효과 (NEURO ‑TTRansform 시험) (전체 분석군)

분석/평가변수	베이스라인, 평균 (SD)		LSM 변화/베이스라인 대비 변화율, (SE) [95% CI]		LSM에서 와이누아 -외부 위약^* 차이 (95% CI)	p-값
분석/평가변수	외부 위약^*	와이누아	외부 위약*	와이누아	LSM에서 와이누아 -외부 위약^* 차이 (95% CI)	p-값
제35주	N = 59	N = 140	N = 59	N = 140
혈청 TTR, g/L ¹,	0.15 (0.04)	0.23 (0.08)
베이스라인 대비 변화율			-14.8% (2.0) [-18.73, -10.80]	-81.2% (1.7) [-84.55, -77.84]	-66.4% (-71.39, -61.47)	p < 0.0001
mNIS+7 종합 점수 ^2,3	74.1 (39.0)	79.6 (42.3)
베이스라인 대비 변화			9.2 (1.9) [5.54, 12.91]	0.2 (1.9) [-3.46, 3.89]	-9.0 (-13.48, -4.54)	p < 0.0001
Norfolk QoL-DN 총점 ^2,3	48.6 (27.0)	43.5 (26.3)
베이스라인 대비 변화			8.7 (2.1) [4.53, 12.81]	-3.1 (2.1) [-7.19, 0.96]	-11.8 (-16.82, -6.76)	p < 0.0001
제65/66주	N = 59	N = 141	N = 59	N = 141
혈청 TTR, g/L ¹	0.15 (0.04)	0.23 (0.08)
베이스라인 대비 변화율			-11.2% (1.9) [-15.06, -7.41]	-81.7% (1.6) [-84.82, -78.48]	-70.4% (-75.17, -65.66)	p < 0.0001⁴
mNIS+7 종합 점수 ¹	74.1 (39.0)	79.8 (42.3)
베이스라인 대비 변화			25.1 (2.4) [20.23, 29.88]	0.3 (2.4) [-4.46, 5.06]	-24.8 (-30.96, -18.56)	p < 0.0001⁴
Norfolk QoL-DN 총점 ¹	48.6 (27.0)	43.3 (26.2)
베이스라인 대비 변화			14.2 (2.4) [9.51, 18.97]	-5.5 (2.3) [-10.03, -0.96]	-19.7 (-25.63, -13.84)	p < 0.0001⁴

* 다른 무작위배정 대조 임상시험 (NEURO ‑TTR)의 외부 위약군.

1 치료, 시간, 치료 ‑시간 간 상호작용, 및 질병 단계, Val30Met 돌연변이, 이전 치료, 및 베이스라인 수치와 베이스라인 ‑시간 간 상호작용에 대한 고정 공변량에 대한 고정 범주형 효과를 적용한 성향 점수 가중치로 조정된 MMRM을 기반으로 하였다. 제66주 분석에는 최대 제66주까지의 데이터를 포함한다.

2 치료, 질병 단계, Val30Met 돌연변이, 이전 치료, 및 베이스라인 수치에 대한 효과를 적용한 성향 점수로 조정된 ANCOVA를 기반으로 하였다. 중간 분석에는 최대 제35주까지의 데이터를 포함한다.

3 제35주 시점에 mNIS+7 또는 Norfolk QoL ‑DN이 결측된 대상자는 대체 모형을 이용하여 값을 곱해 대체하였다.

4 제35주 시점의 통계적으로 유의한 결과로 인해 공식적으로 검증하지 않았다.

마지막 시험약 투여 후 최대 52일까지 수집된 데이터를 기반으로 분석하였다. 전체 분석군의 경우, 에플론테르센군에 제35주 시점에 환자 140명 그리고 제66주 시점에 환자 141명을 포함하였다. 환자 1명이 제35주 시점에 mNIS+7 또는 Norfolk QoL ‑DN 평가를 받지 않았으나 제66주 시점에 이 중 하나 이상에 대한 평가를 받았다.

ANCOVA = analysis of covariance (공분산분석); CI = confidence interval (신뢰구간); LSM = least squares mean (최소제곱법); MMRM = mixed effects model with repeated measures (반복측정을 이용한 혼합효과모형); mNIS+7 = modified Neuropathy Impairment Score +7; N = number of participants in group (군 내 환자수); Norfolk QoL ‑DN = Norfolk Quality of Life ‑ Diabetic Neuropathy questionnaire (Norfolk 삶의 질 ‑ 당뇨병성 신경병증 설문지); SD = standard deviation (표준편차); SE = standard error (표준오차); TTR = transthyretin (트랜스티레틴).

그림 1. 베이스라인으로부터 제65주까지 혈청 TTR 농도의 LSM 변화율, 제65주까지 외부 위약* 대비 와이누아 (NEURO ‑TTRansform 시험) (전체 분석군)<IMG 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">

* 다른 무작위배정 대조 임상시험 (NEURO ‑TTR)의 외부 위약군.

** 제35주 중간 분석 결과로 치료 차이를 볼 수 있다. 제35주 중간 분석에는 최대 제35주까지의 데이터를 포함하였다.

치료, 시간, 치료 ‑시간 간 상호작용, 및 질병 단계, Val30Met 돌연변이, 이전 치료, 및 베이스라인과 베이스라인 ‑시간 간 상호작용에 대한 고정 공변량에 대한 범주형 효과를 적용한 성향 점수 가중치로 조정된 MMRM을 기반으로 하였다.

마지막 시험약 투여 후 최대 28일까지 수집된 데이터를 기반으로 분석하였으며, 제65주까지의 데이터를 포함하였다. 베이스라인, 제5주, 제8주, 제13주, 제23주, 제35주, 제47주, 제59주, 및 제65주 시점에 위약을 평가하였고, 베이스라인, 제5주, 제9주, 제13주, 제25주, 제35주, 제49주, 제57주, 및 제65주 시점에 와이누아를 평가하였다.

95% CI (조정되지 않음)에서 제35주 및 제65주 LS 평균 치료 차이 (와이누아 ‑ 위약)를 제시하였다.

CI = Confidence Interval (신뢰구간); LSM = Least squares mean (최소제곱법); SEM = standard error of mean (평균 표준오차), MMRM = Mixed effects model with repeated measures (반복측정을 이용한 혼합효과모형); TTR = Transthyretin (트랜스티레틴).

그림 2. 베이스라인 대비 mNIS+7 종합 점수의 LSM 변화 (NEURO ‑TTRansform 시험) (전체 분석군)<IMG 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GRAMiAZkAwkgAGulwhRSIKN5sVxBsKf4uhMxUggjH+mjG+rNI1VdJ6qidVwAUzNTMtXqFCpUiVu7SpUqGBubo4DdnwkJAOSAcmAZOA3M8D0qwQnFJK/uQG/+nGaxirRc0HBvXv3njx+wkY1ICDAx8fn0aNHtBIHwhXBDF1CMiAZkAxIBiQDiciAprGKOMRTCUgnT56sWqXqoYMHt2zaPGXKlB07dnTt0uXly5fkEskAioRk4F8YkNmSAcmAZCA+DGgaq4hSIg6tXr26RMkSjZs03rhxY7NmzU6cPOHz9evx48d5KPEMNxQJyYBkQDIgGZAMJCIDmsYq4hDgwZ8/f27YsGGOnDmfPHlSt1693HnyWJibe3l5kSUcUCQkA5IByUAyYOA3d0FOoXEQrmmsogrBY86cOXfu3NmvT19fX99iRYuuXL7i/v37JUqUwIFNlfBBl5AMSAYkA5KBeDHAFBoUFDRv3rzBgwePHj3aycnJwcFh2rRpoaGh8aonWTprGqsgkTNAQtGgQYNMTUyPHTvWp0+fQoUKspkSFgAAEABJREFUHTlypHWbNjVq1CALJEuOZKckA5IBycBvYIApVFdXt2zZsnXq1AkODn758mWtWrXKlSvH9EvWb2jAn/wITWMVTAno6Oj0699v1KhRxKeLFy82adKkTevW0EonCWbI5APZE8mAZEAy8BsZYI5lFv3777+trKzKly9fsmRJFMIVsy7h6jc25E98lKaxirYLHsePH2/TyWbq1Kk2NjZt27Zll9q1a9dbN29BZUREBD54SkgGJAOSAclAfBlgFgViFg0MDOQ8kBpIYkRJ4dA0VkEWAR+y+vbtu3r16pkzZy6O/s2fv2D2nDl58uYhS0IyIBn4/QzIJyYbBphmBegRClJCYUDTWEVsF2XOnDnjun7d1q1b3dzc9uzZs2/f3v379vv4+IhcEc+ELqVkQDIgGZAMSAYShQFNYxVBPiIi6t9F9vLyevfu/ecvX7y9vU+ePLls6dIDB/azXaU1+CghjaSEZEAyIBmQDEgGohn4WaFprCIIAZ42adKks2fPbnJzq1KlCsGpRctWmzdv5g6QLBwAys/g52v4mafLspIByYBk4D9kgAkQiAYoikimcKlprIImIhPchYSEbNu2zbKB5d69e6dPn75py6byFSqQGx4ejgPKj0BZdmZIBRQROnZ0IJI/qkHaJQOSAclAMmaACZDeqUuSzKvCgp6SoWmsgi8BJyenNm3a3Ll7p3Dhwvfu3Rs1YqSzk9OTJ0/ETRU+P2ITugG5+Ajo6ET948LolEUH6AAfiWTGgOyOZEAy8K8MsGrHR5kDmRhJSggGNI1VhBnBY2hoKCd+ZcqUefr06aFDh06eOHHmzBkfHx/4xQeIer+XOIhoxP7p0qVLx48f5+oLo5+fH6Hu4cOHd+/e5Q7s+4LSIhmQDEgGUgIDzIdMoUg6q6enJ2MVPCjQNFaJAvDo7Ox85MiRdevWjZ8wYeLEidNmTJ80aXK+/PnIwkewjPI9RBaBaty4cR06dLC3t2/duvXHjx9PnDjRokULW1vbtm3bUrNw+764tEgGJAOSgV/MwH9fvZgAw8LDnz17pqzdxT7hv2/cf9oCTWMVDIpdkYmJSfr06ZcsWdKpY0c7O7uedj379uv76NEjHES4irs77969W7VqlZ2d3dYtW+/fu3f61KmbN27my5N3+LDhc+fMrV2rdmTUnyeOVCrhoUq1iqLkSkUyIBmQDCRdBpjTAO1HCjCR+n71dZkx8+rlK2fPnF28aDGBSlul6URNVckVCaHgy5cvGzZsqF69+vwF8+fNmzdnzpwC+QtA0L/uWHkZhLrly5cPHjyYV8ILCA8Lf/nixa1btxYuWLB927aoGlRaYaFhLCg4IeRo0dfXV1dXl8olJAOSAclAMmOAaZAeMTESkCK1InWiY9LePXsszM1btmxZr27dt2/eXPA4r9JW4ZbCkZBYZWxsXLlyZUNDwwwZMmTJmjV9uvTsfgSPkC6UWCW5pqamlpaWFy5caNK4cb169erWq/f3339zANi1W9eDBw+uXbOGl/f02dNhw4Y5OjoOGTLE1dUVS6y1JbpRVigZkAxIBn4nA0yJRCmeyDKdtbtWdEy6f/++u7v76tWrc+bMmSNnzi/R/+ISPikcCYlVBA/45SjP2srasn795s2b37lzBx6xA5QfQeRu2rSpU6dO7dq1W7l6Vbp06QoULDjEcUjbdu2yZMny5s0byubKlWvs2LFca40fP75Nmza8TowSkgHJgGQgmTHAlEiUQoLgkJAd23d069L13r17/v7+efLkYfl+6+bNcuXKJbNeJ6w7CYlVHKdevXq1X79+R9zdD7u779mzp0SJEppEFN7H+/fvR44cGRQY9PrNG9vOnXfu2DFp4sSGlg379+v35MkTtmt0I1WqVMStbNmyIS0sLMLCwjBKSAYkA9EMSJH0GFCmR0VR+sCs+PHjxxUrVrRv1273nt1Nmjbd6LaRlXpAQEBgUOBge/tMmTNp/f8bfKVcilMSEqtSp05NIPH09Lx29eqVy5evXLnMrRKMh4eH/yt/XD6xqerZq6eJqYmpmVn2nDmmz5yBfP/hw5Tp0xo3bRLjXRKoqFlUqygiKaVkQDIgGfjzGRBzGmdRQlFv8OPHjydNmsS6/+7du9zir127tnGTxqkMDUuVKW3VyLpK1ap58+WNKiWvq7S0EhKrwsLD9PT0jh8/PmbMGCcnJ7h+9uwZL0C5tUKPFZBubm7OkmHs2LEzZsyYO3cu29uiRYuuWbNm27ZtXWxtiWT4xFpWGiUDkgHJQFJkgEU24KyPyQ1FdOH8+fOOjo5Dhw7FwhQ6e/bsKlWqiCwhQ6N/Qk+SMrEbnZBYZWRktHDhQmLVvn37OFHlDLBUqVI0LNaFA3YFvCqgJNmHUURJksUuiiQKUkIyIBmQDCQPBsScRrgiADFh2tnZzZkzJ3/+/MuXL+dOpECBqP+OGh+QPPr7K3qRkFgF4zly5cybP1+BQgVBvvz5DQ0NRdRhjRBHK8kFvA+cATpAwULcoiA7MyrHiC4hGZAMSAaSAQPMb+Dz588c8dnY2OzYsaNOnTqrov+YKedMTIAgGXTzV3chIbEq1jZBN+8j1izFSBASICAJkERRJIriLJWkzIBsu2RAMvB/DDCthYSETJ48+fLly3379uXKo3Xr1tz6i2wmQICOG0CRiJWBBMaq+3fvjRk12tHewX7QYMchjk+ePmFL9DNE/0zZWDsmjZIByYBk4A9hgJt4bqcWLFgQ41LqD2lekmhGQmKVv7+/vb39ihUr3I8edXd3P3rsqLeXN8FGIEl0WzZSMiAZkAxo/RYKOHBi55Q5c2aehg5QJOLLQEJiVVBgkKen59y5c2/cunn77p3r16+XK1eOM0CeLSSKhGRAMiAZkAzAAIt4JHMjUQodkJSILwPxiFUQDXhA6jSps2bLtnXrVldX17Vr1q53df348SMLB3Lla4AfCcmAZCDZMMC0pg7RLyxCUeT3lhhZzJBMj7gBJSuGop7FrQpFcKAUUiIesQqyBJXh4eFmpqbPnz+fO3vO7Fmz5s+f/+rVK3IFsyhJBLKZkgHJgGQgHgwwAYrtEYpSDB0Iu2JUVwg2ytyIDtRzY+jMrl+jf15eXt++fUNFofIYbikwGY9YBV+wzGUVyvgJE9yif5u3bNmwYUPhwoV5WymQPtllyYBkIEUxwBwIiD2hoaHc1otlemLNftQcEhKyaNEiR0fHM2fOPHjwYOjQoVOnTsWYokiOtbPxiFW8HqgcMmSIvb396FGjbDrZdO3a1damc48edpr/+1WxNkIaJQOSgR8yIDP+UwaY9IBogpgD2eusX7++c+fOq1atYhtELhBZwi3Bkm2AgYFB9+7dx44du3DhwiVLlowePZr5Vk9PL8F1JpuCmsYqFg4CtWrVqlmzJrJ5yxZNmzZt3qJ5kyaNzc3NRW6y4UV2RDIgGZAMKAwQjcDr16/nzJnDGv38+fNdunThSCl37twEGGY/xfMnFZ5iYWGRJUsWJlWQPXv2TJkycXf1k9Umg+KaxioYBHS4VatW7du379Ktq+NQRwfHIY7Dhg4aPDhHjhy8MOGAj4RkQDIgGUhCDBBsAA1mHgPslkgisQhcvXp1zJgx/fv35/bI2dmZTU/dunXZS5HLvIeCRP9J8FDq4bkLFiwgIrLB4qG+vr4/We3vKf6rn6JprKIdkAhQvgdvVxh/5CBypZQMSAYkA38mA8QJ5jFlBkNhN4Pl+PHjffv2nTx5spmZGSFk/PjxxYsXV+8CnurJn9GpiidSg6WlJRsAjv7atWtnaGiIRSIesUqdLN7rjRs3Dh48+PDhww8fPrCs4L3igB0pIRmQDEgGkhADBAkFYjZjN7NlyxYO+lavXl2pUiWuphwcHLJlyyamOCRBBZm4fRRtoM68efMWLFgwX758RYoU0dXV5VkYUzgSEqt4Q4sWLapTp46jo6Orq6utre379+9TOI8pvfuy/5KBpM8AoYJOMJvNnTuXIzh2VNx3rF27tmPHjqampgQMASZAIJzxT0RQJyBYUmdoaKj4dyd4KEmJhMQqb29v13WuTmPGlC5VqkzpMp8+fjx06JCgEqKFEqvkBQuQKxReAwoSC0BHSkgGJAOSgV/NgJhthORZzF337t1zcnLixO/Tp08jR45csmRJ/fr1ReQQDviIJArAmLigMSBGzTwxhiVxH5pUaktIrNJWqUJDQiIjIsH7d+8i1f59ZSXqfN//yMhI7gyxwzu68EQhiZ0VBBaABR8JyYBkQDKQ6AyoV8jMw2yDDAkJYQvVv39/4hP7pzlz5kyaNKl06dI444AUwFMdGEkiExFUCESFKMyHii6UlCwTEqtMzczs7Oxmz57t4eExffr0vHnzNLSyEiTCr1Bildxp4SBev5BYUDiQFWsHpPJ6Yq1BGiUDkgHJQOIywI3G0qVLy5YtKy6lcuTIQf3MS8xFynyFReK/ZSAhsYr317N3L2IVF48sRoYNH54ubVreK283js5Qilx8UADxCYkFCYhSSAGMEpIByYBk4JcywFxE/chWrVoRpTp37pwuXToxjwnJpISDxB/CQEJiFS9ytsuscePGrV2zdvHixe3btbt0+bIm71WEoufPnzs6Onbr1k3ccgUGBrq4uHTv3v3w4cOQQj2MHhQhURINsiLJgGQgZTDA7AHi7isOAlmzZk2dOrXQRRFmKjERYRQWKf9zBhISq7y+fFm2bFm5cuVGjRnNCe/oMWNy58rFSyWGIePukp+fX48ePdzd3f39/Hr2sLt88dL8ufNmzXR5+vgJyQse5ykuKhFSqZMkOrkSkgHJgGQgbgaYLgA+QqJ8D6KRgMgiPgEsSIARKYAu8Z8zkJBYZZTaqECBAlWqVrXtYtu1ezf2zlmyZKEnvGbkjyAGjZeXl7+//8yZMzdt2mxsbLx3795du3b17tPnwMGDbMCJYRQX9QiZKlUqTgsxykEDCRIpgQHZx59kQEw1zBgocoH7k2T+OcUTEqsiI7V8fHyGOjqWKV26RLHiyEuXLjEy6JWQKLGCoZMxY8YjR47UqVOHy0yCVr58+cLCwvLkyWNoZGhhYYGFgr6+vpejf9euXXvw4IGok7JkSUgGJAOSgbgZYMZgpYvEDQUpkQwYSEis4my3TZs2HOVZNrC0srJq1LixRQYLuBCDAyVWkEu8MTAwoDh3XbNcZs2ePbtRo0bcV0VGRFCE3PDwcJS3b9+ujP6tWLHi2LFjwkhxuUSCHAnJgGTgXxm4c+eO+Mcf/tVTOiSUgd9dLt6xavfu3Zza5cyZky1RoUKFihQpki9PPiNDI00aTrxhFzV48OC5c+cOGNi/WIni/gEBqdOkPutx7tatWy9evsicNeossXDhwkuif4sWLerdu7dSs1wiKVRIRTKQAhlgOQtEx1FYvCIBijAiPTw8HBwcuEd//vw5SYlkw0A8YpUYENww7d69Z+3ateyKZkX/Fi5a8Pr1axghFAGUH4Fc9kzUkCZNmvkLFjM5VLIAABAASURBVFSoUOHU6VO9evfevXt3/fr1Tc3MGjdpEqMsmyrGojBSXChSSgYkAymQAWYAwIQggA4JSFaxwcHBO3fu7N69+7x581hAr1mzhilFTFn4SCQDBjSNVQwOeoucOXPmjBkzFi9efOLkyaNRv2MHDhwsUaKEGBY44BYrRBaXUqtXr163bh0bpy1bttSsWdPW1pbkxIkTN27cmC9vXuGm1BAjqdil8t8yIJ8uGfj9DIjZAEl8UvD58+fly5d36dJl37593CkwmXTr1i1dunSK2+9vp3zir2BA01iljAwnJ6eqVas04Fe/vrW1df369aysrDjBY2lD+3BDxgqRZWRkVL169RrRv1q1amXJkoUhVadOHYZX/vz50WMtK42SAcmAZAAGmCKUqebx48eTJ09mL/XgwYN+/fpxx92kSRN9fX3WzQBP5hwkpSSSAQOaxiq6yotHEmAYHHZ2dn369Gnbtm379u3t7HpkzpyZLIYFQPkRxAASuXgCYUERRiklA5IByUAMBsT8gGQKAuRevHhxaPSP+29OelxcXP7++2/szCdIfAD+kZGRKFgkkgED8YhVordNmzbl6rJps2bXr1+/e/cuGyMDAwOkGBnC50eSBZEydFAAFoAiiqAAoUspGZAMpHAGmFVE+IEHZoaQkJCDBw+yVp4zZ07u3LkXLVrEMU++fPnIFWAyQcET6OjoIElKJA8G4h2r6DYjZkC/fmfOnCFWvX37dtSo0SdOnJDDAmYkJAOSgURkgFmF8IP88uULR3xcSm3dupVLh7Vr1/bu3ZvjHIIZj1PiGbpEcmUgIbHKx8fn9p07bL2LFi1apmzZbNmy3bhxA4IYUsg/B7IlkgHJQJJmgFD0/PlzcSl18+ZNrh5WrVrVrFkzLqXoF7nMOUh0iWTPQEJilYmJSYECBcaPH3/16tVpU6a+f/+uWLFiMCVXN5AgIRmQDCQWA4cPHx44cGBwcDDhat68edWrV6dmEZyYbYSCJGJhl0jeDCQkVqVKlWrO3DmFCxdmR2WQymDSpEl16tQRIwYJwqP/+gki2Y4dO27duPnm9RtIjIxQ+zcZSUtIBiQDUQzI//2QgVKlSi1evHjcuHHMNjGcOBsEGJEyVsFDskdCYhWk+Ph8LV++vK2tLZvxiAitsLAwhgtRiizArea6des4VnYYbE+46tC+/ePHT1TaKrIkJAOSAcmAhgxkzJgxa9asTCwCohRTjVCkTFEMJCRWBQcFjxo58ujRo5s2bWLzNG7cWPEvUUEcwwiEhISsWbOmX79+1apVK1qsGNusrZu3kCshGZAMSAY0Z0A9RGleSnr+Egb+60oTEqt8vvp8+PChSpUqT58+Hes8lsuqW7dv0RGiFIfIKEBXV1dPT09LpfXZ01NXRyciMupvp8UuIRmQDEgGJAOSgfgykJBYZWJikilTpqFDh7Lq0dPXu3792l9F/hIP5uwYIweDffr2Wb58+RF3d+exY8MiIjgGFA5SSgYkAymHAWYDIPqLAoQupWQgvgwkJFYZGhpOmDixs63tjJkzCxUs2K5du3r16vFg9lVIhiOHfqEhoSNGjJg7d+7yFcv37N2TO28e7ORKJE0GZKslAwlhQHz1SOYE5gfw8ePHO3fuaFgX/urQsJR0S5YMJCRWQYSFhUWZMmUePLjv7u4eERH5+PFjjIxIwNYKbN68+cyZM9bW1lZWVhwGcoPFmMNHQjIgGUghDDAbiK8eqaOj8/Llyzlz5tjZ2Z04cSKFMCC7mYgMJCRWBQUFDejff/CgQTNnzFy7du2mTW4EJ/U2sYYCGzdu/PvvvytUqFC5cmUPDw91B6lLBiQDyZ4BQpTA7du3R44cOXDgQE9Pz/Hjx/fv3/9X9V3Wm3wZSEis8vHxefjwIYOvYsWK0zkGLFSIfT0UiXGJwnqqS5cu3Ff17Nmza9euDg4OOXLkwC4hGZAMpBwGWLBy7tK3b19nZ+eMGTPOmzdv0qRJJUqUwM4UkXJ4kD1NFAbiEasiIiLECDM2Nk6fPv2LFy/YYI0eNerixYuP/jkDpE34cOjXuHFjzv2uXLr88P6DAvkL5Mkj76vgRkIykBwY4Bv/EUT3/Pz8uAXo1q2bq6srJyucvrCpUhasHMOwrhWeUkoGNGRA01jF0GR4Iak3derUbORZKPWws8uQIYOVtbVlgwbYAQ4C7LpGjx4dHBx8//791q1aeZw9R3EcfiVk3ZIBycDvZiAiImoJy9ct8ObNG/ZPnTp1OnXqVLt27VatWmVjY8PqVr1ZeKonpS4Z0IQBTWMVdRGEkODBgwcRERGc7LGvqlmz5rRp03LlykUuQ5AVE8B+9uzZKVOmrN+44chR92JFi+7cuZOCEpIByUAyY0BHR4dPnk7du3eP5emAAQNevXo1bty4RYsW1a9fX1dXlywJycDPMxCPWCVC0bFjx5o1a9ahQ4eWLVqOGjly2bJlPe3svL29aQoORCwUzgBNTExYWD16+Oiou/uLly+zZcuOXUIyIBnQSi4U8L0DenP69On+/ftzKcXVwMzoX/HixbEzGwAUlrZCQZeQDCSMAU1jlTLUOHrOnSvX8uXL7967y9Zq/fr1N2/cvHv3LqNW8WExxdi9c+dO3bp1u3btWrhIkfYd25MLYrRS/oW2MQiRScnAH86A+Ir53v39/Tdt2tSlS5clS5ZUrFiRZevgwYO5mab9MYKT2Hhhl4gXA5As/AXnQk+xUtNYBWvh0X97uq+vb758+awaWXNTVbhw4TJlylhkyBAaFgaD+ACGKTrb/6FDh06dNnX8hAmTpky2sLDAqI61a9a8efWad/D0ydO5c+a4uLhwlnj9+nV1H6lLBiQDfxoDfOPg2bNnLEM5ZWnZsqWrqysHLWnTplWaSnDCR0AY0YUipYYMcNkfGBgonJknhfI75Z/2rHjEKh0dHVqvq6d38dKlaVOm+vn5rVu3jlDk4+PD0CSLYKZwyiLL3t6+UqVKoaGhnW1sHj16xGAlF5w4cYJD7X59+719+1ZbR/vQwYOTJ085cODA5s2buQmjHgnJgGTgD2eAQ/5Ro0ZxvmJlZcXMwAqVz/8Pb3PSah47gXLlykFs0mr2r2utprFKoSx7tmzcTrGSSp8u/blz57Zs2pQhg4WJsTFNJBrhRtwKCQnZsGEDy65cuXKx7MKyceNG4RAWFnbkyJHLly8bGxsbGBhgfPjgYY0a1fsP6E94a9u2LRZ1CB91i9QlA5KB/5wBc3Nz9Uspvn3wn7cqOTWgcuXK1tbWLO6B5JY3q2mswhXA2ogRI9zd3Q8dPrR565Z9+/YdcXfftHkzSwCilJbq//8LVQb6Bm/evHn44MHjx4+Dg4KMjIwoDrjKmjJlyqJFi/T19SO1ov71xddvXp89e27ihIl2dnY3btzAh2PGK1euEM+Q9+7dU6miquXRgFyJ38GAfEaKYYDPCojuogChxyGFD5+8UPBEYUmKRJdQGNCQEOEmpCir6OxZVaqoCRA7RoAChCIkSaCuk0x+0DRWMRBV0T+uqXLmzJkte/bsObJnz5kjZ+5c2bJlU3Y/uEEZcah3r14nj5+oU7tO29ZtMmfK3KZVa7gjCwnYXal0tCMio2JV3/793Da5cQbIGcL27dvJ/fTp09q1a1euXLl69eqTJ0/q6elhBEpxdAnJgGTg5xkg3ohK+PoASb4yAWGPVTITYOdjRxFAx4KOlIABOBRkogtgQcGIVIARC1AsQoFJshSdJD5YeEeKEQU7UkDo+Ihk8pOaxqq4ey5o0oqMxA09PDSsXoP67kfdOQZs0aLFvHnzCGnkKjzCONSzxwoKCrp48SK7LlNTU4Y7Zakhb9688+fPX7JkycKFC7t3705gw0gWDigSkgHJQGIxwCfJl4UEfF+s4qmZbxOg/Pn4Y1sIn8xyUEoLd+7c+eXLFxRYxQ7Q1SFeAdLT0/PgwYMeHh5i0sOHSp4+fcryHZ3aAOdVHFYB7C9evMCBO5ejR4+eO3cuODgYt+SKBMaq58+fcyO1Jvq3fv36t2/fQrTAx/cfuG5dOH9BWFj4oUOH2CoNGzbsi+dnTgghGh9BZWBgYFhYGHum69evE89q1qwJ482aNSNX8UEHvAwk4E0jJSQDkoHEYoBPkqkTycKR7+7+/ft8bihYsCfWU1JgPXAoAj+hZeTIkSdOnMACIFadDSwKmEVbt27NbGlra2tvbx8aGoqnq6tr+fLlWbWLgshx48bVqlWrefPmjRs3trGxefLkSb9+/QYNGtSxY8fhw4dTG6WSJRISqwgzAwcN6t6j+7Rp07h8mjp1KizDkRjc0Hrz5s0KFSuuXLGCtzV7zhw+gJ27dgn68AEFChRYt25drly5cFi+fLmzs3O7du127NhRunRpAhLgg0FSBGdeDwpAR0pIBiQDicUAny1gPc7dc5cuXbhIZorEIr+1n2RYIfD06dOvX7/evXu3UiH0KjqKkjx8+PCtW7c2btzo4OCwadMmru0/fPwo3si3b9/wZEqk2qFDh+7atWvp0qVMnmWi/mGmB8eOHWPXwMRbsWJFZk48kyUSFKsCAh4/fDRq+MirV69eu3rtwvkLxBhIFEHlydOnbdu2rV6j+oULF6wbNWrStEnR4sXu3b8HfcpbSZcuXYMGDdKnT48xbdq0HBX279+/YMGCVIIPoCpALhaAAoQF5f8g/08yIBnQjAE+IiB8UZj1hP7x40cWiyzPOf9o2bIlq08O5MniW+MzRJFIGAMQCHx8fAg5ffv25YyOOASl4NzZc9OmTpvtMmuWi8uypUvxwchTOFsiXBUtWtTHyzuNUWo9Xb25s2ZXqVy5UoWK4dF/gJUKeXf58+cnRN28cUNfT3/c2HGvXr7Cc+mSJcuXLkuTOjUBjKqSJRISq8zSprWs38DjnMeSRYuXLV26atWqN2/fwg48IjNlzHjnzp3tW7exmihVqiSbqitXrih/xTJvBeAWK8hSIBxICgWprpOUkAxIBjRhgA+T5TbxCQV/viNmvWfPnk2aNIlp9MGDBxwirV69mqN7EahwwE3iZxgQVHMZnydPHkiG/y1btogKX718eZGF/IUL5z3O37p1m/OkptE/aC9btuyUSZOXLV06ffr0e/funTx5slWLVmGhYX7f/AL8AyjOi0O+f/eOS5YutrYmpiZBHHMFBFSsWJGl/1DHoZ+5bcEjOSIhsSogIIB90vUb12GZF4D87OkJ0eL1sKl69+5dt65d8+XLV7ZcOScnpzRp0rBkS47syT5JBv6dgf/cg2+T5TZAoTHMk1yKDBkyhCThysXFpWrVqny8gFyJRGEAboOCgm7dulWoUKEMGTJUqVJlxYoV3F1ReZlyZbp3794t+teuXdssWbJkypSJ1TwHfX379GXRsGjx4patWxGQuFvpP6D/k6dPCFrcePkHBFAnNRw9eiwwKMja2hodWFhYdOvevX379l+/fv3i5YUlWSIhsSoiPNzb25tD1eMnT5w6fZp9a8mSJRlAy5sRAAAQAElEQVTovB5k+YoVOE5dsWrV2nXrIJFD8G3btmXLlo1lXbJkUHZKMvDnM8C3GRYWtnfvXr7HOXPm5M6de9myZdz5c/BO48W3iQ+6RGIxwOFeqlSpuLw/evRo9erVa9aq+f79eyo/dvT4iOHDx48fzzp+6pQpTJ5LliyZN2/enbt3Fi1exMked1TWDa046Lt89cqmzZtNTEwoXrFSxbp1686aNYsazp8/nzVr1ixZs6LXqFHDy8uri03nUaNGcX6YNUsWjMkSCYlVevr6qVOn3rx5s133HradO/fu3fvhw4cMdECs0orUyl+wQMtWLbNmy0qyYcOGHLCiiN1rsiRRdkoy8IcwwIdGS5AAReDTp08c1HPgsXPnTg76Vq5c2atXL3Nzc3JxA3y5QkdKCAagRShRMvpP4/yfEqnFFBel878YOpZoUBbAMKd/derUqV27dv9+/dw2upUrV478du3a7Tuwf8vWrdt37Fi6bBlndxhB1ixZhw8d1qpNaxYQxYoXM0trljFjxrx58nTv1r1Zs2amJqaNra0JYNRcqVJFOzs7Pf2oP3harkL5BQsXcC1WtFjR+QvmpzFOQ1VxgOICwgddKFpa//P/2AEmJEABiiIWN+oW9F+NhMQqGhoVwLNm9Y/+ff7ymdNYGoodGRn9B6lQgPgGUIDwQZGQDEgGEp0B5hE+QKT40MSn9+LFC24+WE1evXp10KBBRCxO41loKk/HTR2KPYUr0AgECaGhoVqq//ubI1Ci7P+ktFCA8ItWonK1tFSqqIRKpWKBbhj909bRCQ0O+erto6WlRRDKniNHlqxZsufIniVrVl1dXV4Z765atWpTpk11Hus8feaMKVOnmpqZ4azS0R5oP6hRk8a6errDR4yoX78+1Xayselo04kiOICGVlY7d+1cvmJF/gIFSCqIVEJstIkkiFb/R8QwcmyGBfAg/JAABSgK/Qr+589y0QyAPw6/FAmJVYz1eQvmc+TKTWC9+vWXLllSvHhx2kpPgFDY/7LJ7dmz54YNG7jTEsZf2hNZuWQgJTPApwdgQNxLXblyhRspe3t75hS+xIULF3JlQi5fIlIibgZgSZA5ZUrUX6v94P79Th06NrKyPup+VKWtunv7Ti+7nl1tu3TuZHPn9h3PT54Txo1fv86VkEMpFgT3ov9mOCZ0JnEehFy+dFnNmjW5F+zds9eHDx+4iOrUqRO3J+RSRLwydJ6LM4q/v/+kiRMb1Ks/YtjwTx8/YXHbsLFxo8b2gwZ/fPeBJKD+L1++8JbZui1fvhwLWLt2bYMGDfr06fPgwQNqwxIDPE6AO7D58+ej88QNruutLBt2aN/h+rVrVIsR6enpyfjh0JimModTz65du7gk69at26NHjw4ePDhmzBg8sfMgoaD/OiQkVtGamTNm0gc6wHmrjU1nzmGVttJJmj5u3DjuEj08PLhOHD169NGjR7FTUOLPZEC2KqkzwEfHpMNXxhW9o6Mjkyxn79x8MKH89ddfonc4CEXKf2WACe3s2bMbN27kumhA/wHc0GfOnLl/374vX7w8d+4cEz0BBs6/+vgMcXA4fvz4jBkzcL5165a7u3umTJmon1wk4NB18ODBnOx1trXdt28fc/1nz88nTpx4/fo1PuzbAApvB/BcinCsN3ny5KxZs65evXrF8uVXLl3mnepoax85cmTEyBHKISQ3XseOHeNgcOrUqQcOHDh77uykSZOKFSt2/fp1HspgoCoFPAKQJJRSGxP46dOnSdIS6ilVqpS/nx89DQ0Nwwju3r3r5uaGQqsoyOpn4MCB+fLle/r06eLFi+nOnj17oIKniDbj+UuRkFhFMF+7Zs3EiRPPnfc4der0p08fxZ90oz+A5oaEhFy7do0rXK4E2XsVKFCAd4ldQjIgGfh1DDBrMK0gmzZtyhzHqYaYNHkiHyZZzCkoJCU0YWDr1q3ly5fPkSMH9/GE/GUrloeFh585c+bV69fEgzJly3Tv0aNkyZLsYAoXLmxmZkagYnLnjipdunTULwgPCAwkhlWpUmXl6lUOQxwIIRXKVwgI9DcyMsLt8ePHPIKYoa0dNRUT/3hHlM2TJ+/s2bOJWEWKFCFJaOT2a+u2bbxTnL2i/2O/wMDACxcu2NraTps2rUSJEkSO3bt2Z8+evXHjxpz3Ojg4xHjXPAJQG/NzUFCQsbFxmjRRl1tEShpv07lzw4YNaRUbR3wAB8h58+bljq158+Zt2rRhkqfy1q1bc6JGqKPLxEhXV1eeIqqlyC9FFEEJeACE0mFOWiMjI7S0VGx+tZRfpBb2bFmzrVm1+tbNm8jHDx8VKRzFuOIiFclACmEgMvrOAAnosiKFgiWxwCcpwBF95cqV2Q2ImsWDRBby90wr4tG/QP6mKmGJ+Y1AUqlSJQtzC+b09evXL164iCne79u3t29es3HZvm17p04db9y6OWrM6KvXr+XIlTN3rlwhwcGpjVLv37sPN6ZBCA/w9/f75seSParpkVr1GtR3cnYyMTENCwvj1ejp6bFToX5yceaJbOYuX77cqmVLu54927dtxx6INnAcZ2JiwpVV7ty5qfbr16h7LwMDg2zZshFCNm7YyLGkrraO1xevZ4+fTJsydegQR9d166iQankKIHCyjSPOnT9/nn02p39Uy/kwDrSNBrRo3nzC+PEVK1Skfozg1etXL1++3Ldn78D+A1zXrosMj3j/9t3UyVOcRo9ZtnQZDhUqVLhz505AQNQf/CL5q5GQWJU+fXqCOVvUqpWrcFRqZGRIQBYNhRStyEhWB2xF6X9gQOCD+w86depk09kGsoSPlJKBlMOAmC8Y/OA39Fo8Tv1BikVR1HOl/iMGiFWBgYGGhoYmpiacIbF54oaG0MJ7HOLoePTYUfdjRzmj27xlC/sYzv2WLl368MFDM1Ozvn369O/Xn0uQ8PBwKtfX14f5r1+/omuptJ4+erx3717OaUkiiT3s3pj0mTlxW7BgQbNmzfr378+FVoB/AA9iV8eBG1WRSxF/f38aQDPQCag0jBhGWCLAgPCwsPwFC27bsd2mUye3jW5BAYG4URDgzIOovEePHs+ePcNOjOGhKOwFP0X/0xZjnJ03bd58/959jKB1q9b79+8/cOggF2D4sJnLmTMnDr379Nnk5hYcFGxhYfH582dYwllUhfLrkJBYxVtky8mmmD4MHmxP62FcsEmU4rjz4/sPhw8f6tmr16LFi1etWUXQ2rVj56/rg6xZMvCHM8B3AWgkswZzDfgN3zaPk0gwA7wvXhY7D/ZS3NCw4GaOxsg52KqVqzzOebx8/sLH2ztNmtQ8goCxY8cOY2NjQgKyW/dux4+fIBiQRbJipYrkHnM/+urVq379+o8eNZq3Dwg5xLAVK1YQPHgWzr17996+fTubHg4Au3Sx5ZyNC5RPHz/yUMpSA5dSGTNmNDQ04lyRk0l2XcQ5NgZGhkZMwnny5AkMCGB39cnTM+qA8cnjDRs2cGVDzYCjvG3btq1cuZLdGEmayjhE4SouKDAoQ4YMZqamvr5fX79+RVRjw0R82rd334cPH9jVmZqYEKh8fHw+e3oSnwjJOtrafn5+7FvYx1OJaD/Kr0NCYhXnm1zl8Radx40dMGgAfRDtg32UDx/eW1tbO4126tG9+4D+/bt26TpkyBBWHFBD7s9AlpUMJDkGmA4EaDnrOYDCt/Abvm0eJJFgBlKlSpU/f35OzFCICsOGDWM2q1evXq3atXV0dEnWq1svQ8aMXWy78Aimb3Zd3bp1s7KyIjZwYNi0aRPufsjiRQ8bOrR06dJdu3atV7sOp2pTp07hHpEdG2GMCDR06NC7d+/iyfxZqFChatWqcUXEedWVK1erV4v6W1W7duvWpl1bLq7atm174sQJ4llgYOAYZyeOClHmz5vPZRLBsk3btgRUBli1KlW43xo+fPj7d+9HjR5FoBWV58qVq2bNmsQ2EV3Yh3GKqKWl1b5d++w5svNEWtKhPXoO9iFXov9iPC7Mates9fTJUzYetJ+nsD/ZtmULPdXV1zt/4TwXWvBDy6nnVyMhsYrlALu/OXPm9LLrOdRhyFDHoY8ePWLFIdqaOUsWrhCrVKvSycbGngu+IUP27N3Tu0/v39Mf0QYpJQN/CANLlizhI+dKnCkGybrt3bt3tI0AhlSH8oGggBgOHApxZKTuL/VfygAxplWrVsSqF8+fL1m6xG3TpoWLFs2aMzt1mtRTp0/dvGWzy2yX7Tt2EM9EM3izufPmKVm61K7du7Zt3z5y1CiVtrZ4iVmzZdu2Y/s6V1eXWbMOHzls2bBh5syZ2T8RltgJEVeqVq1KJTwRyasHhIRDhw5NmDiBA0Mb287EttWrV69ZswZj+44dsmXPxkkVPtzFnDp9ioZtcNuYKXMmGrB7z56Fixft3rO7Tr267MnKlS2nVCsaIx6BdHJy4ggRJX+B/Nt37HBxcXHb5DbDxYX7s507d7LfICAdPHRw8pQpe/bvrVGrpkXGDPRrpsvMbTu29+hlx13WeY/zhEnqJ0AqlVPhL0L8YhUk0g7CUvbs2bmaYzXx8NGjl69estPCLnDv/r28+fO3a98+X/58JmYmZmnNtHV0/IN+0/2baIOUkoH/joH/eTILbRZspUqV4hxi8ODBdnZ2adOmxUNbO/ZPj2+erwwoDjdu3Bg5cmSfPn3eR/8NPZSV+NUMwD9gq0E88Dh/XkdXt0bNGvXq1xMbEV7N35UrWzdqxAmYaIm5uTmvmHdHMlv27H8V/YtJUqWlxTyuFf2jYPUa1a0aWWfPmQMDl1ic75mZmbH3Kl68OAoXK8TFmzdvKkUIIU2bN+PU6uyZMy+ePc+QKSPFCT/nzp579PBRsWLFeGhYcIj/N78CBQsQqKgWWGSwKFO2bKHChdG/fvPlgor7GnRAs5FAPIKauQwjCShF5ZX+/lulrWIrQtuoHHuJ4iWaNG1CQEUH5hbmDa2sSpUujX7q9OkqVaqI/1KBziqVk/WLEPsH8/3DeHO8CTq5atWqtavXsp1kz7R02bKVK1cuXLgwf4ECIpeCu3fvnj5tGqsGbhcHDRzk6OjIt3rv7j3KkishGUhRDDAjMK3w8bO8++uvv1CYnviaYv0cWJ9CDp89wOfYsWN9+/adPHkyxxhz585lnsKIg8SvZkDhecqUKZaWlpo/jmlQvESK8IoBChAVkisU3i9GkkhAoBo4cGCrVq3YzXBepZR69vRZ48aNW7dqjfQ4e87fz79FixatWra0trJiX0WpXr17W1lbsy1bvHhxWFgYd0vLli1r2rSpV/R/1E6Uat++PXGRhyp18rgEg3pos5A0ddasWVSr9DfB1WpYUNNYpVTHIWmffn2mTZvWvVu3BvXr16tbF+Ju3bol2MeNr2v+/PkzZ85cu3YtccvZ2ZnT2+rVq5MlIRlImQwwrfBVK33na1d0oQiLWJ9y387NuY2NDWc+LF2XLl3KhozV4W+bFESTUrJkNmNShnA2NekQcgAAEABJREFUGWIfrAkbvGIK8hKfP3/OWRkTICt1ztOoiixqIFco4iBKSZ46dWrHzh0sSjh2W7BgwZs3b3AG69auRefwkMUKZ4Dbtm69fv36ylUry5cvzyZh/959Bw4ccJk5s127dsSq27dvjx49euzYsR8/fqQsEIMKqQDj/0eCNNF+JLQQBamDXlA/yq+GprGKxgHaBPtjxozh/JQzwMZNmnD22qCBpXn69KKhOKRLl47co0ePTp8+/eDBg2yqOMF48uSJcPhXSQ3/6iMdJANJhQHmKZrKqGbiEwq6+JRQsAhgAVxlRf8HYF1Onz7dsWNHV1dXpiEmBTxFPcJZyl/NAITzOsQsjK7J43DjHQGc2d9MnTKVRcaTx0/69umza+dOXui2bVz3bN+6dSs6IRC3169fs11mRr144UK6tOk6dOjAtikgIODVq1fkAqbNMmXK1Klbp169ek+fPr148WLBggWZcjmI4xEk2bW3bd+uSZMmPj4+NJjJtl+/fpw3isFGDaI9KOQClJ+EqJDOUg9PASiJUjP1xA1NYxW10CDA2eWoUaNWrFrJNeMYpzGTpkweO24siz5aD3ADrCI3bNhQsmTJk8dPVChXPiwkdLPbJuz0Ex8BkvRT6IodBbuEZCCZMcCsp94jviNGvrqFiwpOIDiTYFHM97VkyZL69esrDvhTAwt2FMUolV/HADxDOFJAkwfhyQuiFM7MY6mNjJzGOG3btrVA/gK7d+1et2btooWLFi1cOGfWbPcjRy5euDh44CBbm85nT58pVbKUkaFRakOjiLDwkOCQ0OAQP99vVBIFlYrAg8IOhjqpH5DU4THaUVO3rq6uVqQWWTzd0NCQE+a8efOGhoaK0YXEDnBHUvAnQSWiKhSqQgfogOSvRlSHE/CMokWLpk4d9QcLRFlIUVdIQuLjx4+fPH3K4SkbWNhUdxB9E7yjKx1GF25S/mIGZPW/lQG+COUTEINcjHkacebMGdbCEyZM4IOaN2/e1KlTWUpjl0jSDKhU2myVdHR1CTZMdH379eP+fqzzWC7AOnTouGrFikWLFlWsWHH+ggXtO7TPnDnz+3fv/P39AwMCUqVKxbmU6LuOtra3tzc6G27ClbGxMT4kP3/+zIgi6evrGxgYiGR0iXEVFBTE0AK4YQEoiQhRoSKFkoj1x1FVQmIVNFEju86HDx9++vSJOz3RYoUvaK1Vq9a2bdsKFypkamp64cKFunXrUgRAonDes2cPZdHZ827atIlFJW4kReV4SkgGkgEDDGl6wRfB6g2FpACTzpYtWzp16rRw4UKO05cvXz506NDs2bPjw3kDUiLpMkBwCg0NnTZt6lgnZ+7yy5Yrt3DBAvvBg0eMGDFo0KBlS5eOGevMYe/du3c5vnN0GFIgf/40xsa2tracB7I3MrewqF2r1sYNG62srT08PGw7d2aGrFGjBlttNgA2HTtxclihQoUmTZtytcnJIddUhQoVypo16p9e5LnMzMlyFk1IrOJjO+LuXrNmTb60VatWcfEr/uQHb4jhJSLWkCFDdu3a1a17d2LVihUrqlSrGhkRSUFyxX+D27lz55cvX+Lv4uJCDTt27OAymfdKMMMoIRlIHgww5r28vA4dOvTgwQNmFjrFTQNr6q5du7q7u3MptW7dOqYbLqUiIiKYYoD8BGDp/5A0/y8iIsIk+ud+9OiAAQOY6wYOHMiiZM7sORwE2vXsmS1btj79+m7ZupX9tLm5eZ68edlS+/n5ZcyQkWt+8/Tm5cqWy5QhQ/Pmzfv06XPv7j3usXr37l21WtWxY8dyicWGbIijY9FiRdmlsSHj1opS7MsZPCVKlOCJ4r81TZrk/bDVCYlVcDp5wkSOWTNlyJjRIsORI0cOHT7MNwlTvCTxqCtXrhCE7Hr0aNum7VF39wB/fy2VFj6EfTc3N77SVAYGhqkMQ4KCd+7Y0cW2CychHNru2bVHFFckO2iqFUlFEUkpJQN/PgNv37ydNHGSv5+f15cvTDSzZs1i9uFS3d7enr0UK2W2XAxsQIhSqVT0SKWKkigSSYsBXqKYAJnlvnh9GTR48DmPcyNGjUydJnWxEsXLV6xQtkK5Sn9XKlS4EAt3uqZvoF+vfr1hI4anTZ+uvmWDo8eP7dq7u2TpUvqp9KdOn1arbh1dPV3ncWMvXbk8Z95cfLR1dHr16e1x4fy69a45c+Xkce06tD9/8QK7glKlSpGkznLlyrF7I26hJzMkJFZxQur1xatd27Ycs2bJkiV9uvR8e/DCe1KpVHxyvKpp06aRnDVntvNYZzawm9w2kYVFT09v8uTJ7GFTGaSiCFWFhYb9VaSImZlZBgsLX9+ov+Hxy5cv+/fv37179759+86fP8/HjKeEZCApMnDk8KESxYt379qtoWXDvHnyRv3XzDNnTpkyhTMcpTt8GkAkFUUkpUxCDIhoQYOZFTnQMzUzRcfIvIeiDpV2IixHYgwVkkB5CjpQkslASUisSp8+fd16ddmTsj3iWpjbPGsrK7gQZ4AoHLh//Pixe/fubF179LQrXqLE/ftRf3cvbwj6cCP8ENIiwsN5i2FhYZGUiQa5/D/nrYQoDw8PNlv37t3DIoCzUKSUDCQVBhjijHBO91jAhYaGcI+bJ0+epNJ42c54McCcxgzG7Jc/f34O5XLlyoVODdiREj/JQEJiFdTzJsZPmMCZe48ePTZs3FigQAHawXsiC4WDO24IR40aNWL4CG4Cr127xuUWdrHzReHrDQ2L+g8rjVJzsmp05/Ztjkrevn1rYmxCbt68eSdOnMjODFB/SEgIRgnJQFJkwNq60fXr15ctW3bw4MFXr15Xr15dLLSRICn2SLb5RwwoLxQFKG7qumKUSnwZSEis8vf3d3Z2ZlPFLR83xrNcXJo1bbp3zx4t3klEpNj9jB8/vkmTJufPe3CgxzF9g3/+nhLiGU3EUUtLFRYebpAqVbPmzVasWFGzRo3Q0FCrRtZaWlpEMmS0jxaHhCL+kWRDhl1CMvDbGGDUxf2sb9++ffznrwmI1TNT5kxcOVhkyJA1a1ZnZ6d06dLhxpAWnwm6RDJjQExxSAYPMsG98/PzE/8xDvUkuJLkVDAhsYo7p0uXLp0+dSpVqlTv3r07sH9/UGDQxAkTXz5/ySmflkoFuRYWFmXKlMmWLTsnHiVLltTW0cbIm0OyLy5YsOA613X5CuTnix1sbz977pyONp02uG0sWaok5Cr/dS86oAiSskgJycDvYYBRx0DlWSgARQGLKq6d3NzcRo8e3atXLxQl63uFsubm5nXq1mG0m0X/rbViJLPwEsr3RaQliTLACwUsRJB0ASl0FJLxxYEDB1atWiVKMYqA0FOsTEisCgwIJOZzTLdk2dL9+/cXKliwZcuWGTNmfPzkcTSPUf9t+rDhwwcMGPD582cPD49mzZodP3pMvDAY5/2xuqxRo4apSdSJH4eAnTp1cnJyKleuHKELh+hKpJAM/AcMMPyAGIcinDBuAU3hjHrv3r2TJ0+2s7MbM2bMzZs38+fPz0E3F7fkxo3AwEB5lB03RTI3BgNBQUFMsxjF8BOSZIKR1AsmJFaxSeIzdnV1Xbd23YQJE169fn3q1KmHDx+KP26trdLms7x8+fKw4cMOHT508dJF7p/OnD0LU9BNoEIBTAec9WFhamABiwTYhUSRkAz8fgYYkIBRCni6j4/PkSNH5s2bx73pkCFDTp48aWxsTHBatGjR1KlTO3fuXKRIEW5n5aCFK4nEZYBxKE6YGF0gcStPirUlJFbxuc6ePZsDwAnjx7PS7Nevn6WlZYcOHQoVKqQVGXVpxSFhtqxZr129dvHCxUMHD3HqaqCvf/HiRbZZgnQheRlCIfIRupIifbLNyY8BFrPnz59fvXp13759+/fvv2vXLnZFNjY2c+bMcXFxwVK+fHmT6CMBRq8Yt4zk5MeD7NF/zgADjDYIiZLCkZBYBWVcQQ0dOtTJ2ZkzkDp1aje0tnYa66yrrxcZGcF3ywfMmf7hw4c7tG/ft08fFqfrXde3aNb87Nmz5EZGRv036iiEKCS1AZax6AIkJRKZAVldnAxwEnDv3r0NGzYQiji7Xrx48evXr5s2bTpu3Di2UMOGDatatSqn3NQhRi8KYLgi44biryj484EAFAnJwI8YYHQBcpFMjygpHAmJVcHBwb179WrUqNHkSZOGDxvWomWrBw+i/vhU1OenUiFh1tnZeceOHctXrGB9yg3hosWL1q9fX7FiReWL5QVAPRIIRUiRRJeQDPweBm7dutWlSxfuX+/evUtMYhG2bt06LlDr1q2b57s/CxVjfDLU426k4sDKTHjyCVAJEEkpJQOxMsA4idWeYo0JiVW+X7+e8/BwcHDYsnXL5q1bN2/eXDj6n0yGRAIVku/z5cuXS5YsmTtnzmyOTubMSZs2bY1aNcWFFg4SkoE/hwELC4uBAweyopo8eXLr1q2jjrKjG5cok4WXl9f79+89PT05CUf58OEDRw5UL2MVJHwPaZEM/IiBhMQqE1NTzgA5NsmRI0e+fPly5c5laGgoHsAXCMiaPn06hypFixUrXqI4kYzoxUWWEsnwEf5SSgb+cwYyZ87MFRT3rwQnBYnVKjc3N3t7+yNHjnz69Gn48OFjx44lXDH+w8PDE+sRsh7JQEpgICGxKiw8/PPnzzNnzqxauWqZ0qVr167NKQpk8QXyqaMQmTJnymRtbT1x0sRJLFanTvmraFE+TmIVDkh0FDwlJAM/w4AyilBAgquiLKA4Y1iAJMDyk+B0kRsvwL5t7ty506ZNy5IlCzXzjfxkzd8X58uiZoHvcxWLcEDij1FIkugKvk8qFhSAJxKgSEgGfgMDCYlVerq6I0eO3L59+9RpU2fPnu1gb29mZibaGvUFRkRyNF8gX/5VK1ZWLF+hQrny4NTJUzq6UT8cAA7MCKLI/5dSkwz8gAHmREAmkrkViQ4UheEEwsLC7ty5s2bNGhcXF39/fxw0BGUFFH+SDFQlmWDFyMiIA3BjY+PUqVPzmZiamjL41buQ4JpjFIQKgJHKkZqAPuJMqRgQS0mMVIIUEDr+KABFsZOUkAz8agYSEqv09fX53vbs3Xvs2LFDhw8dPnyEbRYNZewy+lU62iHBIecvXvzrr79sbW27devG0jJb9mycAeIjIRlIAAMMLUDBqAEW/T90QDjB/uzZs3379om/RYJt/P3797lzYmWEw38Omnfx4sXdu3cfOnSIk8DAwEDRJOxCSUQJMdSGBCixQjwXCYQb3zKe6FhQAKwCLAQkgAUdoIgkngALSRTsEpKBX81AQmLVt2/fxjo779qxY9/evffu3rt69UqaNGloKGOXgQsY/Tlz5ChevLiVtXWtWrXq1q2bKVOmqP9QHScJyUD8GWDqBKIcwwzly5cvLJWmTp3at2/fUaNGnThxIm/evL179165ciXnbFZWVqyocPsViFedtPbp06cbN26cOXPm3bt3xX9YQV+w8373GvAAABAASURBVKXEq6q4nalQVIskhPzIGTeAD8AHXTQDBQtSgBoAFr5lLHiSxJMVAEnsAEUkyZWQDPxqBhISq/z9/D2/fJk+Y0bpMmX69++fI0fOO3fvKg1lBDOmPT09N2zYUK9u3Xr16jVo0MDj3Dnsio9UJAMJYMDX1/f06dOLFy8mJvXp02fv3r16enpt2rRZtmwZh35s38uUKWNoaMgRFhNrAur/FUX4Ftq3b9+rV6/KlSsPHjzYxMQEC80Tc33iPvHhw4ePH0f9PWdx/+NIrDXXr1+/YsUK4r36V/nu3bulS5dyth8cHEzzQFBQEAsCTlZxE6DBV69effToEUncjh49ikVCMvAbGEhIrEqbLm2unLl27drFqqpfv35nzpwOCQ6mrXyEyKjvUEd74OBBCxYtHGw/ePjw4cwjRYoUiYyQOyvokYgfA0yX169fZ90zYMAAZnwUDpxbt27NRemcOXMcHByqV6/ObZB6pWwFmGeZTNWN/63OdgqINtA2Wij0n5R8a3x0QlLVgnnzly1dhqJSaWNEIVdA6MigwMC+vftMnjRp/tx5vex6+n37BlHg48ePnNiPdRrbu2ev6dOmhYWGQfuoESOHOAwJDQmlIMBt27ZtgwYN4rqaz3/GjBn29vbOzs6sIcjlQeKh6BJ/AAPJrQkJiVUGBgZz5sxmPcsNAXLU6NFNmjRhpDKUxWDlUyxatKiHh4erq+umTZs+eXpm5b4q7sVeciNW9uenGGDtv3PnzmHDhnHfuXDhQq6gateuzbS4ZMmSMWPG1KxZM0uWLDyAUYf88yG+i1/RThjguwMfP3xg03n48OEP7z9oqbSIiFpaWtgFtLSidC0trXv377u7u69YvmLrli3nzp47fvw4RsAO6datW7t37xoxYsTmTZvfvHnjunYdkUlPV1dbFTVL8CDcWBZwO/jy5cv8+fN7eXk9f/6c3RV7WXIBz8JHQjLwKxiIGoUJqJcrYo/z51lYMae8ef36w4cPSiV8JBzCDB06lNODhg2tihUr5uzktHP7DjmOFYqk8q8M+Pj4sK4vUaIEA2nBggUTJ05kPVSwYEFGEXMiiIiIYJj9az3J3gEq4IRunj17rmHDhh/evz986BBJDvQI6o7RP84ez5w5Q1AJCAiANPy9vb19o3ZUWrjhDAg/2bJmLV+xwl9//eXv789+a9r0aYMGD2Y7GBkZgQOlkLyCefPmcVhSoEAB3ggHiU2bNuUklizhgCIhGfgVDCQkVjHo+QQ2ubmxqnrw4MHDh48IXWKkEqhoZUhIyJMnT1gFjxg5Yu78eaVLlz5//jx2id/GQFJ/UPbs2cePH89ND+EqVapURKbIf36MNFQkfURBSrDFefvu7fARw1karnddHxEeFcj5KjlB5Wsl3ty+fbtly5aVq1Q5c/qMjY3NqJEj+YT5TnX19BT29PT0taLP6YlnFNHT1zfQ1+eLVkhGyZUrV4voH/GJ01eOVSpWrChqIFe8FJGUUjKQuAxoGqsYiEA8m+Hr5+c3bdq0YyeOnz575oj7ESYUkcWcgqKvr58xY8b58+cTzxbOX/DgwYOiRYthjwEqFP7CLpJIkZQyiTKQiG+Q4UFtSEEFUyFJdBQk4xCgJBuI3tEdFAF0AUgA6NhRkAAeAEZO//Lly2dqZta4SZOzHmdPnDhhbm5epkyZSpUqEUsqVapUuHDhv//+u6GlZa7cuWrWqjli1KhevXvppzJgTcAW9suXLxYWFu8/vGebRczT0dXJkjUr1YYRtSLCo+MXUSzq/3k

복약정보

- 월 1회 피하주사하는 약입니다.
- 아밀로이드증 환자 관리에 대해 지식이 있는 진료의가 처방과 감독을 해야합니다.
- 이 약으로 치료를 받는 환자는 1일 권장섭취량의 비타민 A 보충이 권장됩니다.
- 2℃~ 8℃에서 냉장 보관하며, 빛으로부터 보호하기 위해 상자 그대로 보관하세요.

의약품 정보

금지약물 여부

금지목록 국제표준 분류

경기기간 중 금지약물 사용 시 주의사항

주사제 사용 시 주의사항

검색하신 약물 및 방법이 금지약물 또는 방법에 해당하나요?

효능 · 효과

용법 · 용량

사용상의 주의사항

복약정보

금지약물 정보

분류제목

KPIC 의약품 상세 정보